Clinically Applicable AI System for Accurate Diagnosis, Quantitative Measurements, and Prognosis of COVID-19 Pneumonia Using Computed Tomography.

Journal: Cell
Published Date: May 4, 2020

Abstract

Many COVID-19 patients infected by SARS-CoV-2 virus develop pneumonia (called novel coronavirus pneumonia, NCP) and rapidly progress to respiratory failure. However, rapid diagnosis and identification of high-risk patients for early intervention are challenging. Using a large computed tomography (CT) database from 3,777 patients, we developed an AI system that can diagnose NCP and differentiate it from other common pneumonia and normal controls. The AI system can assist radiologists and physicians in performing a quick diagnosis especially when the health system is overloaded. Significantly, our AI system identified important clinical markers that correlated with the NCP lesion properties. Together with the clinical data, our AI system was able to provide accurate clinical prognosis that can aid clinicians to consider appropriate early clinical management and allocate resources appropriately. We have made this AI system available globally to assist the clinicians to combat COVID-19.

Authors

  • Kang Zhang
    Xifeng District People's Hospital, Qingyang, China.
  • Xiaohong Liu
    Department of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China. Electronic address: lvj221@163.com.
  • Jun Shen
    Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, Guangdong, China. shenjun@mail.sysu.edu.cn.
  • Zhihuan Li
    Center for Translational Innovations and Department of Respiratory and Critical Care Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China.
  • Ye Sang
    The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
  • Xingwang Wu
    Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Yunfei Zha
    Department of Radiology, Department of Infection Prevention and Control, Renmin Hospital, Wuhan University, Wuhan, China.
  • Wenhua Liang
    Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Chengdi Wang
    Department of Pulmonary and Critical Care Medicine, Med-X Center for Manufacturing, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  • Ke Wang
    China Electric Power Research Institute, Haidian District, Beijing 100192, China. wangke1@epri.sgcc.com.cn.
  • Linsen Ye
    Department of Radiology, and Liver Disease Center, Sun Yat-Sen Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Ming Gao
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
  • Zhongguo Zhou
    Faculty of Medicine, Macau University of Science and Technology, Macau, China.
  • Liang Li
    School of Psychological and Cognitive Sciences, Peking University, Beijing, 100871, China.
  • Jin Wang
    Cells Vision (Guangzhou) Medical Technology Inc., Guangzhou, China. Electronic address: wangjin@cellsvision.com.
  • Zehong Yang
    Departments of Urology, Radiology, Emergency Medicine, and Respiratory Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Huimin Cai
    Guangzhou Kangrui Co. Ltd, Guangzhou, China.
  • Jie Xu
    Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang Province 310000, China.
  • Lei Yang
    George Mason University.
  • Wenjia Cai
    Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Wenqin Xu
    Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA.
  • Shaoxu Wu
    Departments of Urology, Radiology, Emergency Medicine, and Respiratory Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Wei Zhang
    The First Affiliated Hospital of Nanchang University, Nanchang, China.
  • Shanping Jiang
    Departments of Urology, Radiology, Emergency Medicine, and Respiratory Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Lianghong Zheng
    YouHealth AI, 510005 Guangzhou, China.
  • Xuan Zhang
  • Li Wang
    College of Marine Electrical Engineering, Dalian Maritime University, Dalian, China.
  • Liu Lu
    Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China; Guangzhou Kangrui AI Technology Co. and Guangzhou HuiBoRui Biological Pharmaceutical Technology Co., Ltd, Guangzhou, China.
  • Jiaming Li
    Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China; Guangzhou Kangrui AI Technology Co. and Guangzhou HuiBoRui Biological Pharmaceutical Technology Co., Ltd, Guangzhou, China.
  • Haiping Yin
    Gansu International Travel Healthcare Center, Lanzhou, Gansu 730030, China.
  • Winston Wang
    Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA.
  • Oulan Li
    Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 510005 Guangzhou, China; Shiley Eye Institute, Institute for Engineering in Medicine, Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Charlotte Zhang
    Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China.
  • Liang Liang
    Department of Computer Science, University of Miami, Coral Gables, FL.
  • Tao Wu
    Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, Xinjiang, 830011, China.
  • Ruiyun Deng
    Faculty of Medicine, Macau University of Science and Technology, Macau, China; Guangzhou Kangrui AI Technology Co. and Guangzhou HuiBoRui Biological Pharmaceutical Technology Co., Ltd, Guangzhou, China.
  • Kang Wei
    Faculty of Medicine, Macau University of Science and Technology, Macau, China.
  • Yong Zhou
    National Institutes for Food and Drug Control, Beijing, 100050, China.
  • Ting Chen
    CAS Key Laboratory of Tropical Marine Bio-resources and Ecology (LMB), Guangdong Provincial Key Laboratory of Applied Marine Biology (LAMB), South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. chan1010@scsio.ac.cn.
  • Johnson Yiu-Nam Lau
    Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong, China.
  • Manson Fok
    Institute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Macau, China.
  • Jianxing He
    Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China.
  • Tianxin Lin
    Departments of Urology, Radiology, Emergency Medicine, and Respiratory Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. Electronic address: lintx@mail.sysu.edu.cn.
  • Weimin Li
    Department of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Guangyu Wang
    State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, Beijing 100876, China.

Keywords

External Resources

Popular Topics
Recent Journals