Disrupted rich-club network organization and individualized identification of patients with major depressive disorder.

Journal: Progress in neuro-psychopharmacology & biological psychiatry
Published Date: Aug 18, 2020

Abstract

BACKGROUND: Altered structural and functional brain networks have been extensively studied in major depressive disorder (MDD) patients. However, whether the differential connectivity patterns in the rich-club organization, assessed from structural brain network analyses, and the associated connections of these regions are particularly susceptible to depression remain unclear.

Authors

  • Xinyi Liu
    Department of Pharmacy, Second Xiangya Hospital, Central South University, Changsha 410011, China.
  • Cancan He
    Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
  • Dandan Fan
    Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
  • Yao Zhu
    Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
  • Feifei Zang
    Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
  • Qing Wang
    School of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, China. qwang@163.com.
  • Haisan Zhang
    Psychology School of Xinxiang Medical University, Xinxiang, Henan 453003, China; Xinxiang Key Laboratory of Multimodal Brain Imaging, Henan Provincial Mental Hospital, Xinxiang Medical University, Xinxiang, Henan 45300, China; Department of Psychiatry, Henan Provincial Mental Hospital, Xinxiang Medical University, Xinxiang, Henan 45300, China.
  • Zhijun Zhang
  • Hongxing Zhang
    Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453002, Henan, China; Department of Psychology, Xinxiang Medical University, Xinxiang 453002, Henan, China.
  • Chunming Xie
    Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China; Neuropsychiatric Institute, Affiliated ZhongDa Hospital, Southeast University, Nanjing, Jiangsu 210009, China. Electronic address: chmxie@163.com.

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