Transcription factor expression as a predictor of colon cancer prognosis: a machine learning practice.

Journal: BMC medical genomics
Published Date: Sep 21, 2020

Abstract

BACKGROUND: Colon cancer is one of the leading causes of cancer deaths in the USA and around the world. Molecular level characters, such as gene expression levels and mutations, may provide profound information for precision treatment apart from pathological indicators. Transcription factors function as critical regulators in all aspects of cell life, but transcription factors-based biomarkers for colon cancer prognosis were still rare and necessary.

Authors

  • Jiannan Liu
    Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Chuanpeng Dong
    Depart of BioHealth Informatics, School of Informatics and Computing, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
  • Guanglong Jiang
    Depart of BioHealth Informatics, School of Informatics and Computing, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
  • Xiaoyu Lu
    Department of Neurology, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang Province, China.
  • Yunlong Liu
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Huanmei Wu
    Temple University College of Public Health, Philadelphia, PA.

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