PharmGKB Tutorial for Pharmacogenomics of Drugs Potentially Used in the Context of COVID-19.

Journal: Clinical pharmacology and therapeutics
PMID: 32978778

Abstract

Pharmacogenomics (PGx) is a key area of precision medicine, which is already being implemented in some health systems and may help guide clinicians toward effective therapies for individual patients. Over the last 2 decades, the Pharmacogenomics Knowledgebase (PharmGKB) has built a unique repository of PGx knowledge, including annotations of clinical guideline and regulator-approved drug labels in addition to evidence-based drug pathways and annotations of the scientific literature. All of this knowledge is freely accessible on the PharmGKB website. In the first of a series of PharmGKB tutorials, we introduce the PharmGKB coronavirus disease 2019 (COVID-19) portal and, using examples of drugs found in the portal, demonstrate some of the main features of PharmGKB. This paper is intended as a resource to help users become quickly acquainted with the wealth of information stored in PharmGKB.

Authors

  • Rachel Huddart
    Department of Biomedical Data Science, Stanford University, Stanford, California, USA.
  • Michelle Whirl-Carrillo
    Department of Biomedical Data Science, Stanford University, Stanford, California, USA.
  • Russ B Altman
    Departments of Medicine, Genetics and Bioengineering, Stanford University, Stanford, California, United States of America.
  • Teri E Klein
    Department of Biomedical Data Science, Stanford University, Stanford, California, USA.

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