AIMC Topic: Pharmacogenomic Testing

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Risk prediction for delayed clearance of high-dose methotrexate in pediatric hematological malignancies by machine learning.

International journal of hematology Jun 25, 2021
This study aimed to establish a predictive model to identify children with hematologic malignancy at high risk for delayed clearance of high-dose methotrexate (HD-MTX) based on machine learning. A total of 205 patients were recruited. Five variables ...
Nomograms Methotrexate Alleles Antimetabolites, Antineoplastic ROC Curve Polymorphism, Single Nucleotide Genotype Pharmacogenomic Testing Humans Machine Learning Biomarkers Reproducibility of Results Hematologic Neoplasms Risk Assessment Child
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Transfer learning enables prediction of CYP2D6 haplotype function.

PLoS computational biology Nov 2, 2020
Cytochrome P450 2D6 (CYP2D6) is a highly polymorphic gene whose protein product metabolizes more than 20% of clinically used drugs. Genetic variations in CYP2D6 are responsible for interindividual heterogeneity in drug response that can lead to drug ...
Deep Learning Computational Biology DNA Pharmaceutical Preparations Humans Neural Networks, Computer Phenotype Computer Simulation Cytochrome P-450 CYP2D6 Supervised Machine Learning Haplotypes Alleles Microsomes, Liver Base Sequence Polymorphism, Genetic Pharmacogenomic Testing
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PharmGKB Tutorial for Pharmacogenomics of Drugs Potentially Used in the Context of COVID-19.

Clinical pharmacology and therapeutics Oct 24, 2020
Pharmacogenomics (PGx) is a key area of precision medicine, which is already being implemented in some health systems and may help guide clinicians toward effective therapies for individual patients. Over the last 2 decades, the Pharmacogenomics Know...
COVID-19 Drug Treatment Gene Ontology Medication Therapy Management Pharmacogenomic Testing Pharmacogenetics Antiviral Agents Knowledge Bases Humans COVID-19 Precision Medicine
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Building the drug-GO function network to screen significant candidate drugs for myasthenia gravis.

PloS one Apr 4, 2019
Myasthenia gravis (MG) is an autoimmune disease. In recent years, considerable evidence has indicated that Gene Ontology (GO) functions, especially GO-biological processes, have important effects on the mechanisms and treatments of different diseases...
Databases, Pharmaceutical Pharmacogenomic Testing Etanercept Carnosine Organometallic Compounds Gene Ontology Myasthenia Gravis Zinc Compounds Databases, Genetic Adalimumab Immunosuppressive Agents Glucosamine Humans Drug Repositioning Thalidomide Gene Regulatory Networks Genetic Association Studies
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Contemporary pharmacogenetic assays in view of the PharmGKB database.

Pharmacogenomics Mar 18, 2019
AIM: Six modern PGx assays were compared with the Pharmacogenomics Knowledge Base (PharmGKB) to determine the proportion of the currently known PGx genotypes that are assessed by these assays.
Humans Databases, Factual Pharmacogenetics Genotype Knowledge Bases Pharmacogenomic Testing
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Gene-Specific Variant Classifier (DPYD-Varifier) to Identify Deleterious Alleles of Dihydropyrimidine Dehydrogenase.

Clinical pharmacology and therapeutics Feb 2, 2018
Deleterious variants in dihydropyrimidine dehydrogenase (DPD, DPYD gene) can be highly predictive of clinical toxicity to the widely prescribed chemotherapeutic 5-fluorouracil (5-FU). However, there are very limited data pertaining to the functional ...
Antimetabolites, Antineoplastic Cell Survival Mutation, Missense Predictive Value of Tests HEK293 Cells Risk Assessment Humans Pharmacogenomic Variants Structure-Activity Relationship Dihydrouracil Dehydrogenase (NADP) Gene Frequency Pharmacogenetics Machine Learning Models, Molecular Pharmacogenomic Testing Protein Conformation Genotype Computer Simulation Fluorouracil Dose-Response Relationship, Drug Inhibitory Concentration 50 HCT116 Cells
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Comprehensive Characterization of Antidepressant Pharmacogenetics: A Systematic Review of Studies in Major Depressive Disorder.

Clinical and translational science Jun 1, 2025
Pharmacogenetics is a promising strategy to facilitate individualized care for patients with Major Depressive Disorder (MDD). Research is ongoing to identify the optimal genetic markers for predicting outcomes to antidepressant therapies. The primary...
Treatment Outcome Antidepressive Agents Pharmacogenomic Testing Pharmacogenomic Variants Humans Depressive Disorder, Major Pharmacogenetics
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Evaluation of clinical impact of pharmacogenomics knowledge involved in CPIC guidelines on Chinese pediatric patients.

Pharmacogenomics Feb 1, 2020
To evaluate the clinical benefits of implementing pharmacogenomics testing for Chinese pediatric patients.   Based on the drug-gene interactions involved in the Clinical Pharmacogenetics Implementation Consortium guidelines, whole-genome sequencing ...
Knowledge Bases Practice Guidelines as Topic Prescription Drugs Pharmacogenomic Testing Clinical Competence Pharmacogenetics Humans Child Precision Medicine Asian People
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Drug knowledge bases and their applications in biomedical informatics research.

Briefings in bioinformatics Jul 19, 2019
Recent advances in biomedical research have generated a large volume of drug-related data. To effectively handle this flood of data, many initiatives have been taken to help researchers make good use of them. As the results of these initiatives, many...
Pharmacogenomic Testing Social Media Drug Repositioning Drug Interactions Machine Learning Drug-Related Side Effects and Adverse Reactions Humans Knowledge Bases Data Mining Algorithms Systems Integration Computational Biology Databases, Pharmaceutical Drug Development
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