Automatic Segmentation Using Deep Learning to Enable Online Dose Optimization During Adaptive Radiation Therapy of Cervical Cancer.

Journal: International journal of radiation oncology, biology, physics
Published Date:

Abstract

PURPOSE: This study investigated deep learning models for automatic segmentation to support the development of daily online dose optimization strategies, eliminating the need for internal target volume expansions and thereby reducing toxicity events of intensity modulated radiation therapy for cervical cancer.

Authors

  • Bastien Rigaud
    Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: BSRigaud@mdanderson.org.
  • Brian M Anderson
  • Zhiqian H Yu
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Maxime Gobeli
    Polyclinique Bordeaux Nord Aquitaine, Bordeaux, France.
  • Guillaume Cazoulat
    Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Jonas Söderberg
    RaySearch Laboratories, Stockholm, Sweden.
  • Elin Samuelsson
    RaySearch Laboratories, Stockholm, Sweden.
  • David Lidberg
    RaySearch Laboratories, Stockholm, Sweden.
  • Christopher Ward
  • Nicolette Taku
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Carlos Cardenas
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Dong Joo Rhee
  • Aradhana M Venkatesan
    Medical Physics Graduate Program, MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas; Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Christine B Peterson
    Department of Biostatistics, Division of Basic Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
  • Laurence Court
    Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Stina Svensson
    RaySearch Laboratories, Stockholm, Sweden.
  • Fredrik Löfman
    RaySearch Laboratories, Stockholm, Sweden.
  • Ann H Klopp
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
  • Kristy K Brock
    Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas.