CKLF and IL1B transcript levels at diagnosis are predictive of relapse in children with pre-B-cell acute lymphoblastic leukaemia.

Journal: British journal of haematology
PMID: 33620089

Abstract

Disease relapse is the greatest cause of treatment failure in paediatric B-cell acute lymphoblastic leukaemia (B-ALL). Current risk stratifications fail to capture all patients at risk of relapse. Herein, we used a machine-learning approach to identify B-ALL blast-secreted factors that are associated with poor survival outcomes. Using this approach, we identified a two-gene expression signature (CKLF and IL1B) that allowed identification of high-risk patients at diagnosis. This two-gene expression signature enhances the predictive value of current at diagnosis or end-of-induction risk stratification suggesting the model can be applied continuously to help guide implementation of risk-adapted therapies.

Authors

  • Stephen Fitter
    Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.
  • Alanah L Bradey
    Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.
  • Chung Hoow Kok
    Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.
  • Jacqueline E Noll
    Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.
  • Vicki J Wilczek
    Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.
  • Nicola C Venn
    Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia.
  • Tamara Law
    Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia.
  • Sakrapee Paisitkriangkrai
    School of Computer Science, The University of Adelaide, Adelaide, SA, Australia.
  • Colin Story
    Department of Haematology-Oncology, Women's and Children's Hospital, Adelaide, SA, Australia.
  • Lynda Saunders
    Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.
  • Luciano Dalla Pozza
    Cancer Centre for Children at The Children's Hospital at Westmead, Westmead, NSW, Australia.
  • Glenn M Marshall
    1 Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia ; 2 School of Women's and Children's Health, University of New South Wales, Kensington, Australia ; 3 Children's Cancer Institute Australia, University of New South Wales, Lowy Cancer Centre, Randwick, Australia.
  • Deborah L White
    Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.
  • Rosemary Sutton
    1 Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia ; 2 School of Women's and Children's Health, University of New South Wales, Kensington, Australia ; 3 Children's Cancer Institute Australia, University of New South Wales, Lowy Cancer Centre, Randwick, Australia.
  • Andrew C W Zannettino
    Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.
  • Tamas Revesz
    Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.

Keywords

External Resources

Popular Topics
Recent Journals