AIMC Topic: Chemokines
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Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction network.
Cell
Apr 23, 2025
In humans, selective and promiscuous interactions between 46 secreted chemokine ligands and 23 cell surface chemokine receptors of the G-protein-coupled receptor (GPCR) family form a complex network to coordinate cell migration. While chemokines and ...
Plasma Cytokine and Chemokine Profiles Predict Efficacy and Toxicity of Anti-CD19 CAR-T Cell Therapy in Large B-Cell Lymphoma.
Clinical lymphoma, myeloma & leukemia
Feb 20, 2025
BACKGROUND: Anti-CD19 chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a promising treatment for large B-cell lymphoma (LBCL); however, durable complete responses are achieved in only 30% to 40% of patients. Additionally, CAR-T therapy...
A machine learning model revealed that exosome small RNAs may participate in the development of breast cancer through the chemokine signaling pathway.
BMC cancer
Nov 21, 2024
BACKGROUND: Exosome small RNAs are believed to be involved in the pathogenesis of cancer, but their role in breast cancer is still unclear. This study utilized machine learning models to screen for key exosome small RNAs and analyzed and validated th...
Integrating chemokines and machine learning algorithms for diagnosis and bleeding assessment in primary immune thrombocytopenia: A prospective cohort study.
British journal of haematology
Sep 10, 2024
Primary immune thrombocytopenia (ITP) is an autoimmune bleeding disorder, and chemokines have been shown to be dysregulated in autoimmune disorders. We conducted a prospective analysis to identify potential chemokines that could enhance the diagnosti...
CKLF and IL1B transcript levels at diagnosis are predictive of relapse in children with pre-B-cell acute lymphoblastic leukaemia.
British journal of haematology
Feb 23, 2021
Disease relapse is the greatest cause of treatment failure in paediatric B-cell acute lymphoblastic leukaemia (B-ALL). Current risk stratifications fail to capture all patients at risk of relapse. Herein, we used a machine-learning approach to identi...
Chemokines
Recurrence
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
MARVEL Domain-Containing Proteins
Transcriptome
Female
Adolescent
Male
Child, Preschool
Risk Assessment
Child
Infant
Humans
Acute Disease
Machine Learning
Survival Analysis
Predictive Value of Tests
Treatment Failure
Interleukin-1beta
Analysis of differentially expressed genes in rheumatoid arthritis and osteoarthritis by integrated microarray analysis.
Journal of cellular biochemistry
Mar 4, 2019
BACKGROUND: Rheumatoid arthritis (RA) and osteoarthritis (OA) were two major types of joint diseases. This study aimed to explore the mechanism underlying OA and RA and analyze their difference by integrated analysis of multiple gene expression data ...
Oxidative Phosphorylation
Inhibitor of Apoptosis Proteins
Arthritis, Rheumatoid
Signal Transduction
Synovial Membrane
Osteoarthritis
Ubiquitin-Protein Ligases
Gene Expression Regulation
Gene Ontology
Humans
Gene Expression Profiling
Oligonucleotide Array Sequence Analysis
Chemokines
Protein Interaction Maps
Gene Regulatory Networks
Serum Concentrations of New Predictive Cardiovascular Disease Biomarkers in Mexican Women Exposed to Lead.
Archives of environmental contamination and toxicology
Dec 20, 2017
The purpose of this study was to evaluate lead exposure and its relationship with serum levels of predictive CVD biomarkers [asymmetric dimethylarginine (ADMA), adipocyte fatty acid-binding protein (FABP4), adiponectin, and chemerin] in women living ...
An immune-inspired swarm aggregation algorithm for self-healing swarm robotic systems.
Bio Systems
May 10, 2016
Swarm robotics is concerned with the decentralised coordination of multiple robots having only limited communication and interaction abilities. Although fault tolerance and robustness to individual robot failures have often been used to justify the u...
The association between clinically suspect arthralgia and adipokines in obese patients.
Acta reumatologica portuguesa
Jan 1, 2018
OBJECTIVE: Obesity is a moderate low-grade chronic inflammatory condition. The cause of low-grade inflammation in obese patients who have clinically suspect arthralgia (CSA) may be the subject of debate in clinical practice. Our aim is to determine w...
Chemerin Blood Levels are Associated with MRI Measured Volumes of Abdominal Adipose Tissue Compartments and Lifestyle Choices.
Acta clinica Croatica
Dec 1, 2017
Obesity is a low-grade chronic inflammatory state, in which a cytokine chemerin with its immunometabolic modulation has an important role. We aimed to study in a healthy population relationships between serum chemerin levels, lifestyle choices and ma...
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