Diagnosis and risk stratification in hypertrophic cardiomyopathy using machine learning wall thickness measurement: a comparison with human test-retest performance.

Journal: The Lancet. Digital health
Published Date:

Abstract

BACKGROUND: Left ventricular maximum wall thickness (MWT) is central to diagnosis and risk stratification of hypertrophic cardiomyopathy, but human measurement is prone to variability. We developed an automated machine learning algorithm for MWT measurement and compared precision (reproducibility) with that of 11 international experts, using a dataset of patients with hypertrophic cardiomyopathy.

Authors

  • João B Augusto
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Rhodri H Davies
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Anish N Bhuva
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Kristopher D Knott
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Andreas Seraphim
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Mashael Alfarih
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Clement Lau
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK.
  • Rebecca K Hughes
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Luís R Lopes
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Hunain Shiwani
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK.
  • Thomas A Treibel
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Bernhard L Gerber
    Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Woluwe St Lambert, Belgium; Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium.
  • Christian Hamilton-Craig
    The Prince Charles Hospital, Brisbane, QLD, Australia; Centre for Advanced Imaging, University of Queensland and Griffith University School of Medicine, QLD, Australia.
  • Ntobeko A B Ntusi
    Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa; Hatter Institute of Cardiovascular Research in Africa and Cape Universities Body Imaging Centre, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
  • Gianluca Pontone
    Department of Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Milind Y Desai
    Heart and Vascular Institute Cleveland Clinic, Cleveland, OH, USA.
  • John P Greenwood
    Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, and Leeds Teaching Hospitals NHS Trust, UK.
  • Peter P Swoboda
    Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, and Leeds Teaching Hospitals NHS Trust, UK.
  • Gabriella Captur
    Institute of Cardiovascular Science, University College London, London, UK.
  • João Cavalcante
    Minneapolis Heart Institute, Department of Cardiology, Abbott Northwestern Hospital, Minneapolis, MN, USA; Valve Science Center, Minneapolis Heart Institute Foundation, Minneapolis, MN, USA.
  • Chiara Bucciarelli-Ducci
    Bristol Heart Institute, Bristol National Institute of Health Research Biomedical Research Centre, University Hospitals Bristol NHS Trust and University of Bristol, Bristol, UK.
  • Steffen E Petersen
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK.
  • Erik Schelbert
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Cardiovascular Magnetic Resonance Center, UPMC Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Charlotte Manisty
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • James C Moon
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK. Electronic address: j.moon@ucl.ac.uk.