The use of a next-generation sequencing-derived machine-learning risk-prediction model (OncoCast-MPM) for malignant pleural mesothelioma: a retrospective study.

Journal: The Lancet. Digital health
PMID: 34332931

Abstract

BACKGROUND: Current risk stratification for patients with malignant pleural mesothelioma based on disease stage and histology is inadequate. For some individuals with early-stage epithelioid tumours, a good prognosis by current guidelines can progress rapidly; for others with advanced sarcomatoid cancers, a poor prognosis can progress slowly. Therefore, we aimed to develop and validate a machine-learning tool-known as OncoCast-MPM-that could create a model for patient prognosis.

Authors

  • Marjorie G Zauderer
    Thoracic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA. Electronic address: zauderem@mskcc.org.
  • Axel Martin
    Biostatistics Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Jacklynn Egger
    Druckenmiller Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Hira Rizvi
    Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Michael Offin
    Thoracic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
  • Andreas Rimner
    Memorial Sloan Kettering Cancer Center, New York, New York.
  • Prasad S Adusumilli
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Valerie W Rusch
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Mark G Kris
    Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Jennifer L Sauter
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Marc Ladanyi
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Ronglai Shen
    Biostatistics Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Keywords

External Resources

Popular Topics
Recent Journals