Investigation of meropenem stability after reconstitution: the influence of buffering and challenges to meet the NHS Yellow Cover Document compliance for continuous infusions in an outpatient setting.

Journal: European journal of hospital pharmacy : science and practice
PMID: 32296506

Abstract

OBJECTIVES: To determine the influence of different buffers, pH and meropenem concentrations on the degradation rates of meropenem in aqueous solution during storage at 32°C, with the aim of developing a formulation suitable for 24-hour infusion in an ambulatory elastomeric device, compliant with the latest National Health Service Pharmaceutical Quality Assurance Committee Yellow Cover Document (YCD) requirements.

Authors

  • Conor Jamieson
    Pharmacy Department, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
  • Michael Charles Allwood
    Biopharma Stability Testing Laboratory Ltd, Nottingham, UK.
  • Donata Stonkute
    Biopharma Stability Testing Laboratory Ltd, Nottingham, UK.
  • Andrew Wallace
    Biopharma Stability Testing Laboratory Ltd, Nottingham, UK.
  • Alan-Shaun Wilkinson
    Biopharma Stability Testing Laboratory Ltd, Nottingham, UK.
  • Tim Hills
    Pharmacy Department and OPAT Service, Nottingham University Hospitals NHS Trust, Nottingham, UK.

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