AIMC Topic: Buffers

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Investigation of meropenem stability after reconstitution: the influence of buffering and challenges to meet the NHS Yellow Cover Document compliance for continuous infusions in an outpatient setting.

European journal of hospital pharmacy : science and practice Jan 13, 2019
OBJECTIVES: To determine the influence of different buffers, pH and meropenem concentrations on the degradation rates of meropenem in aqueous solution during storage at 32°C, with the aim of developing a formulation suitable for 24-hour infusion in a...
Meropenem Chromatography, High Pressure Liquid Humans Ambulatory Care Anti-Bacterial Agents State Medicine Drug Stability Infusions, Intravenous Buffers Hydrogen-Ion Concentration
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Assessment of the stability of citrate-buffered flucloxacillin for injection when stored in two commercially available ambulatory elastomeric devices: INfusor LV (Baxter) and Accufuser (Woo Young Medical): a study compliant with the NHS Yellow Cover Document (YCD) requirements.

European journal of hospital pharmacy : science and practice Sep 18, 2018
OBJECTIVES: To investigate the effect of pH and buffers on the degradation rate of flucloxacillin and to determine if flucloxacillin can be stabilised using a buffered diluent for up to 14 days when stored at 2°C-8°C including a 24-hour infusion peri...
Citrates Drug Packaging Elasticity Floxacillin Elastomers Humans Pharmaceutical Solutions Anti-Bacterial Agents Buffers Infusions, Intravenous State Medicine Drug Stability Drug Storage United Kingdom
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A novel electrochemiluminescence sensor coupled with capillary electrophoresis for simultaneous determination of quinapril hydrochloride and its metabolite quinaprilat hydrochloride in human plasma.

Talanta Nov 4, 2017
A novel electrochemiluminescence (ECL) sensor with composite consisted of silica-sol, Zinc oxide nanoparticles (ZnO NPs), polyvinylpyrrolidone (PVP) and tris(2, 2'-bipyridine) ruthenium (II) was constructed. A new method for simultaneous determinatio...
Humans Antihypertensive Agents Silicon Dioxide Zinc Oxide Povidone Electrodes Electrophoresis, Capillary Buffers Electrochemical Techniques Metal Nanoparticles Limit of Detection Luminescent Measurements Quinapril Tetrahydroisoquinolines Biotransformation Calibration Coordination Complexes 2,2'-Dipyridyl
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Polydopamine-assisted partial hydrolyzed poly(2-methyl-2-oxazolinze) as coating for determination of melamine in milk by capillary electrophoresis.

Talanta Dec 21, 2015
Nitrogen-rich melamine (66% by mass) had been found to be illegally adulterated to milk products and animal feed in order to increase the apparent protein content, and ingestion of melamine may lead to the formation of kidney stones. Hence, the devel...
Buffers Polyamines Triazines Electric Conductivity Food Contamination Indoles Reproducibility of Results Limit of Detection Electrophoresis, Capillary Animals Polymers Hydrolysis Hydrogen-Ion Concentration Milk
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Large volume preconcentration and determination of nanomolar concentrations of iron in seawater using a renewable cellulose 8-hydroquinoline sorbent microcolumn and universal approach of post-column eluate utilization in a Lab-on-Valve system.

Talanta Dec 18, 2015
We report on a Lab-On-Valve (LOV) configuration for analyte preconcentration from milliliter sample volumes using confluent mixing in the holding coil for in-line addition of loading buffer. The system was applied to the spectrophotometric determinat...
Reproducibility of Results Cellulose Limit of Detection Color Seawater Chelating Agents Iron Analytic Sample Preparation Methods Phenanthrolines Hydrogen-Ion Concentration Oxyquinoline Solid Phase Extraction Buffers
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HPLC METHOD FOR SEPARATING ENANTIOMERS OF IMIDAZOLE DERIVATIVES - ANTIFUNGAL COMPOUNDS.

Acta poloniae pharmaceutica May 1, 2017
The aim of this study was to test separation possibility of enantiomers of nine active substances belonging to imidazole derivatives: bifonazole, butoconazole, econazole, enilconazole, fenticonazole, isoconazole, miconazole, sertaconazole and tiocona...
Buffers Antifungal Agents Hydrogen-Ion Concentration Chromatography, High Pressure Liquid Solvents Imidazoles
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DEVELOPMENT AND VALIDATION OF FAST REVERSED-PHASE HPLC METHOD FOR ANALYSIS OF ESOMEPRAZOLE IN RABBIT PLASMA.

Acta poloniae pharmaceutica Mar 1, 2017
The present study focused to develop rapid, accurate and sensitive reversed-phase high pressure liquid chromatography method for the quantification of esomeprazole (ESO) magnesium in rabbit plasma. Chromatographic separation was achieved isocraticall...
Hydroxides Proton Pump Inhibitors Esomeprazole Potassium Compounds Spectrophotometry, Ultraviolet Methanol Buffers Rabbits Reproducibility of Results Chromatography, Reverse-Phase Hydrogen-Ion Concentration Acetonitriles Animals Cold Temperature Chromatography, High Pressure Liquid Solvents Limit of Detection Freezing Drug Stability Drug Monitoring Linear Models
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REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR DETERMINATION OF 5-FLUOROURACIL IN RABBIT PLASMA.

Acta poloniae pharmaceutica Mar 1, 2017
A simple, efficient, accurate and selective HPLC method has been developed and validated successfully for the estimation of 5-fluorouracil in rabbit plasma. The drug was eluted by using Supelco C18 column (1.5 cm x 4.6 mm, 5 μm) with a mobile phase c...
Reproducibility of Results Animals Water Linear Models Hydrogen-Ion Concentration Buffers Perchlorates Limit of Detection Fluorouracil Chromatography, Reverse-Phase Reference Standards Drug Monitoring Chromatography, High Pressure Liquid Calibration Antimetabolites, Antineoplastic Methanol Solvents Rabbits
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DEVELOPMENT AND VALIDATION OF HPLC ANALYTICAL METHODS USED-FOR DETERMINATION OF ASSAY, CONTENT UNIFORMITY AND DISSOLUTION OF IMMEDIATE RELEASE CANDESARTAN CILEXETIL 32 MG TABLETS.

Acta poloniae pharmaceutica Mar 1, 2017
New analytical methods have been developed and validated on high performance liquid chromatography (HPLC) to assess the assay, content uniformity and dissolution of immediate release candesartan cilexetil 32 mg tablets. Method development studies wer...
Drug Compounding Linear Models Buffers Chemistry, Pharmaceutical Tetrazoles Benzimidazoles Angiotensin II Type 1 Receptor Blockers Solubility Drug Liberation Biphenyl Compounds Solvents Limit of Detection Hydrogen-Ion Concentration Tablets Chromatography, High Pressure Liquid Temperature Reproducibility of Results
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