The role of deep learning-based survival model in improving survival prediction of patients with glioblastoma.
Journal:
Cancer medicine
PMID:
34453413
Abstract
This retrospective study has been conducted to validate the performance of deep learning-based survival models in glioblastoma (GBM) patients alongside the Cox proportional hazards model (CoxPH) and the random survival forest (RSF). Furthermore, the effect of hyperparameters optimization methods on improving the prediction accuracy of deep learning-based survival models was investigated. Of the 305 cases, 260 GBM patients were included in our analysis based on the following criteria: demographic information (i.e., age, Karnofsky performance score, gender, and race), tumor characteristic (i.e., laterality and location), details of post-surgical treatment (i.e., time to initiate concurrent chemoradiation therapy, standard treatment, and radiotherapy techniques), and last follow-up time as well as the molecular markers (i.e., O-6-methylguanine methyltransferase and isocitrate dehydrogenase 1 status). Experimental results have demonstrated that age (Elderly > 65: hazard ratio [HR] = 1.63; 95% confidence interval [CI]: 1.213-2.18; p value = 0.001) and tumors located at multiple lobes ([HR] = 1.75; 95% [CI]: 1.177-2.61; p value = 0.006) were associated with poorer prognosis. In contrast, age (young < 40: [HR] = 0.57; 95% [CI]: 0.343-0.96; p value = 0.034) and type of radiotherapy (others include stereotactic and brachytherapy: [HR] = 0.5; 95%[CI]: 0.266-0.95; p value = 0.035) were significantly related to better prognosis. Furthermore, the proposed deep learning-based survival model (concordance index [c-index] = 0.823 configured by Bayesian hyperparameter optimization), outperformed the RSF (c-index = 0.728), and the CoxPH model (c-index = 0.713) in the training dataset. Our results show the ability of deep learning in learning a complex association of risk factors. Moreover, the remarkable performance of the deep-learning-based survival model could be promising to support decision-making systems in personalized medicine for patients with GBM.
Authors
Keywords
Adult
Age Factors
Aged
Bayes Theorem
Brain Neoplasms
Chemoradiotherapy
Deep Learning
DNA Modification Methylases
DNA Repair Enzymes
Female
Glioblastoma
Humans
Isocitrate Dehydrogenase
Karnofsky Performance Status
Male
Middle Aged
Predictive Value of Tests
Proportional Hazards Models
Radiotherapy
Retrospective Studies
Sex Factors
Survival Analysis
Tumor Suppressor Proteins