In vitro study of the nephrotoxicity of total Dahuang (Radix Et Rhizoma Rhei Palmati) anthraquinones and emodin in monolayer human proximal tubular epithelial cells cultured in a transwell chamber.

Journal: Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
PMID:

Abstract

OBJECTIVE: To examine changes in the morphology and physiological functions of human proximal tubular epithelial cells (HK-2 cells) caused by total Dahuang (Radix Et Rhizoma Rhei Palmati) anthraquinones (TDA) and emodin.

Authors

  • Chunyu Cao
    Safety Evaluation Center for Chinese Materia Medica, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
  • Lianqiang Hui
    Safety Evaluation Center for Chinese Materia Medica, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
  • Chun Li
    College of Information Science and Technology, Nanjing Forestry University, 159 Longpan Road, Nanjing 210037, China.
  • Yifei Yang
    Safety Evaluation Center for Chinese Materia Medica, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
  • Jiyuan Zhang
    Quality Standard Center for Chinese Materia Medica, Capital Medical University, Beijing 100010, China.
  • Ting Liu
    School of Public Health, Shanxi Medical University, Taiyuan 030000, China.
  • Ran Hao
    Department of Sciences and Education, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
  • Yi Zhang
    Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.