AIMC Topic: Kidney Tubules, Proximal

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Recellularization of scaffolds derived from precision-cut kidney slices.

Biomedical materials (Bristol, England) Oct 3, 2025
The global rise in chronic kidney disease necessitates innovative solutions for end-stage renal disease that can help to overcome the limitations of the only available treatment options, transplantation and dialysis. Tissue engineering presents a pro...
Extracellular Matrix Kidney Tubules, Proximal Kidney Materials Testing Animals Epithelial Cells Cell Adhesion Cell Proliferation Decellularized Extracellular Matrix Humans Tissue Scaffolds Tissue Engineering
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Pan-Renal Cell Carcinoma classification and survival prediction from histopathology images using deep learning.

Scientific reports Jul 19, 2019
Histopathological images contain morphological markers of disease progression that have diagnostic and predictive values. In this study, we demonstrate how deep learning framework can be used for an automatic classification of Renal Cell Carcinoma (R...
Image Processing, Computer-Assisted Support Vector Machine Deep Learning Kidney Tubules, Proximal Kidney Neoplasms Cell Nucleus Area Under Curve Humans Libraries, Digital Carcinoma, Renal Cell
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In vitro study of the nephrotoxicity of total Dahuang (Radix Et Rhizoma Rhei Palmati) anthraquinones and emodin in monolayer human proximal tubular epithelial cells cultured in a transwell chamber.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Oct 1, 2019
OBJECTIVE: To examine changes in the morphology and physiological functions of human proximal tubular epithelial cells (HK-2 cells) caused by total Dahuang (Radix Et Rhizoma Rhei Palmati) anthraquinones (TDA) and emodin.
Rheum Gene Expression Regulation gamma-Glutamyltransferase Absorption, Physicochemical L-Lactate Dehydrogenase Hepatitis A Virus Cellular Receptor 1 Epithelial Cells Cell Proliferation Anthraquinones Emodin Kidney Tubules, Proximal Glucose Cell Line Actins Neoplasm Proteins Humans
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A Systems Toxicology Approach for the Prediction of Kidney Toxicity and Its Mechanisms In Vitro.

Toxicological sciences : an official journal of the Society of Toxicology May 1, 2019
The failure to predict kidney toxicity of new chemical entities early in the development process before they reach humans remains a critical issue. Here, we used primary human kidney cells and applied a systems biology approach that combines multidim...
Primary Cell Culture Sequestosome-1 Protein Toxicology Cell Shape Kidney Tubules, Proximal Machine Learning Humans Databases, Factual Cells, Cultured Heme Oxygenase-1 Data Mining Gene Expression Regulation Systems Biology Risk Assessment Cell Nucleus Kidney Diseases
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