Accurate diagnosis and prognosis prediction of gastric cancer using deep learning on digital pathological images: A retrospective multicentre study.

Journal: EBioMedicine
Published Date:

Abstract

BACKGROUND: To reduce the high incidence and mortality of gastric cancer (GC), we aimed to develop deep learning-based models to assist in predicting the diagnosis and overall survival (OS) of GC patients using pathological images.

Authors

  • Binglu Huang
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, 430060, China.
  • Shan Tian
    Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Na Zhan
    Department of Pathology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, 430060, China.
  • Jingjing Ma
    Department of Geriatrics, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, 430060, China.
  • Zhiwei Huang
    Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576, Singapore.
  • Chukang Zhang
    Ankon Technologies Co., Ltd, Wuhan, China.
  • Hao Zhang
    College of Mechanical and Electrical Engineering, Henan Agricultural University, Zhengzhou, 450002, China.
  • Fanhua Ming
    Ankon Medical Technologies Co, Ltd, Shanghai, China.
  • Fei Liao
    Ministry-of-Education Key Laboratory of Laboratory Medical Diagnostics, College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.
  • Mengyao Ji
    School of Computer Science and Technology, Beijing Institute of Technology, Beijing, China.
  • Jixiang Zhang
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, 430060, China.
  • Yinghui Liu
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, 430060, China.
  • Pengzhan He
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, 430060, China.
  • Beiying Deng
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, 430060, China.
  • Jiaming Hu
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, 430060, China.
  • Weiguo Dong
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, 430060, China. Electronic address: dongweiguo@whu.edu.cn.