Obesity as a Risk Factor for Accelerated Brain Ageing in First-Episode Psychosis-A Longitudinal Study.

Journal: Schizophrenia bulletin
PMID: 34080013

Abstract

BACKGROUND: Obesity is highly prevalent in schizophrenia, with implications for psychiatric prognosis, possibly through links between obesity and brain structure. In this longitudinal study in first episode of psychosis (FEP), we used machine learning and structural magnetic resonance imaging (MRI) to study the impact of psychotic illness and obesity on brain ageing/neuroprogression shortly after illness onset.

Authors

  • Sean McWhinney
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Marian Kolenic
    National Institute of Mental Health, Klecany, Czech Republic.
  • Katja Franke
    Structural Brain Mapping Group, Department of Neurology, Jena University Hospital, Jena, Germany.
  • Marketa Fialova
    National Institute of Mental Health, Klecany, Czech Republic.
  • Pavel Knytl
    National Institute of Mental Health, Klecany, Czech Republic.
  • Martin Matejka
    National Institute of Mental Health, Klecany, Czech Republic.
  • Filip Španiel
    National Institute of Mental Health, Klecany, Czech Republic.
  • Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada (Hajek, Cooke, Alda); Prague Psychiatric Centre/ National Institute of Mental Health, Prague, Czech Republic (Hajek, Kopecek, Novak, Hoschl, Alda); Charles University, 3rd Faculty of Medicine, Prague, Czech Republic (Kopecek, Novak, Hoschl, Alda).

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