AIMC Topic: Psychotic Disorders
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Exposotypes in psychotic disorders.
Scientific reports
Aug 8, 2025
Psychiatry lags in adopting etiological approaches to diagnosis, prognosis, and outcome prediction compared to the rest of medicine. Etiological factors such as childhood trauma (CHT), substance use (SU), and socioeconomic status (SES) significantly ...
MentalAId: an improved DenseNet model to assist scalable psychosis assessment.
BMC psychiatry
Jul 30, 2025
BACKGROUND: The escalating mental health crisis during and post-COVID-19 underscores the urgent need for scalable, timely, cost-effective assessment solutions for general psychotic disorders. Regretfully, traditional symptom-based, one-to-one assessm...
AI-based prediction of depression symptomatology in first-episode psychosis patients: insights from the EUFEST and RAISE-ETP clinical trials.
Psychological medicine
Jul 30, 2025
BACKGROUND: Depressive symptoms are highly prevalent in first-episode psychosis (FEP) and worsen clinical outcomes. It is currently difficult to determine which patients will have persistent depressive symptoms based on a clinical assessment. We aime...
Detecting schizophrenia, bipolar disorder, psychosis vulnerability and major depressive disorder from 5 minutes of online-collected speech.
Translational psychiatry
Jul 12, 2025
Psychosis poses substantial social and healthcare burdens. The analysis of speech is a promising approach for the diagnosis and monitoring of psychosis, capturing symptoms like thought disorder and flattened affect. Recent advancements in Natural Lan...
Prognostic predictions in psychosis: exploring the complementary role of machine learning models.
BMJ mental health
Jun 26, 2025
BACKGROUND: Predicting outcomes in schizophrenia spectrum disorders is challenging due to the variability of individual trajectories. While machine learning (ML) shows promise in outcome prediction, it has not yet been integrated into clinical practi...
Enhancing early detection and treatment of psychosis in Germany: a protocol for the health economic evaluation of an artificial intelligence-guided complex intervention.
BMJ open
Jun 18, 2025
INTRODUCTION: Psychosis, characterised by chronic symptoms often emerging in youth, imposes a substantial burden on individuals and healthcare systems. While early detection and intervention can mitigate this burden, there is limited evidence on the ...
Causal Discovery Analysis Reveals Insights into Psychosis Proneness, Brain Function, and Environmental Factors among Young Individuals.
Psychiatry research. Neuroimaging
Jun 8, 2025
Experiencing mild symptoms of psychosis, like delusions and hallucinations, occurs sometimes in general, nonclinical populations, often termed psychosis proneness (PP), potentially part of the psychosis continuum. Understanding the neural and environ...
Machine learning for classification of pediatric bipolar disorder with and without psychotic symptoms based on thalamic subregional structural volume.
BMC psychiatry
Jun 3, 2025
BACKGROUND: The thalamus plays a crucial role in sensory processing, emotional regulation, and cognitive functions, and its dysregulation may be implicated in psychosis. The aim of the present study was to examine the differences in thalamic subregio...
Relapse prediction using wearable data through convolutional autoencoders and clustering for patients with psychotic disorders.
Scientific reports
May 29, 2025
Relapse of psychotic disorders occurs commonly even after appropriate treatment. Digital phenotyping becomes essential to achieve remote monitoring for mental conditions. We applied a personalized approach using neural-network-based anomaly detection...
Longitudinal brain age in first-episode mania youth treated with lithium or quetiapine.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Apr 13, 2025
It is unclear if lithium and quetiapine have neuroprotective effects, especially in early stages of bipolar and schizoaffective disorders. Here, an age-related multivariate brain structural measure (i.e., brain-PAD) at baseline and changes in respons...
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