A Machine learning model trained on dual-energy CT radiomics significantly improves immunotherapy response prediction for patients with stage IV melanoma.

Journal: Journal for immunotherapy of cancer
PMID:

Abstract

BACKGROUND: To assess the additive value of dual-energy CT (DECT) over single-energy CT (SECT) to radiomics-based response prediction in patients with metastatic melanoma preceding immunotherapy.

Authors

  • Andreas Stefan Brendlin
    Department of Diagnostic and Interventional Radiology, Universitätsklinikum Tübingen, Tubingen, Germany.
  • Felix Peisen
    Department of Diagnostic and Interventional Radiology, Universitätsklinikum Tübingen, Tubingen, Germany.
  • Haidara Almansour
    From the Department of Diagnostic and Interventional Radiology, Eberhard Karls University, Tuebingen University Hospital, Tuebingen.
  • Saif Afat
    Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University Tuebingen, Tuebingen, Germany.
  • Thomas Eigentler
    Center of Dermatooncology, Department of Dermatology, Eberhard Karls Universitat Tubingen, Tubingen, Germany.
  • Teresa Amaral
    Center of Dermatooncology, Department of Dermatology, Eberhard Karls Universitat Tubingen, Tubingen, Germany.
  • Sebastian Faby
    Siemens Healthcare GmbH, Forchheim, Germany.
  • Adria Font Calvarons
    Computed Tomography, Siemens Healthcare GmbH, Erlangen, Germany.
  • Konstantin Nikolaou
    Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str.3, 72076 Tübingen, Germany.
  • Ahmed E Othman
    Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University Tuebingen, Tuebingen, Germany; Department of Neuroradiology, University Medical Centre, Johannes Gutenberg University Mainz, 55131 Mainz, Germany. Electronic address: ahmed.e.othman@googlemail.com.