International Validation of the SORG Machine-learning Algorithm for Predicting the Survival of Patients with Extremity Metastases Undergoing Surgical Treatment.

Journal: Clinical orthopaedics and related research
PMID: 34491920

Abstract

BACKGROUND: The Skeletal Oncology Research Group machine-learning algorithms (SORG-MLAs) estimate 90-day and 1-year survival in patients with long-bone metastases undergoing surgical treatment and have demonstrated good discriminatory ability on internal validation. However, the performance of a prediction model could potentially vary by race or region, and the SORG-MLA must be externally validated in an Asian cohort. Furthermore, the authors of the original developmental study did not consider the Eastern Cooperative Oncology Group (ECOG) performance status, a survival prognosticator repeatedly validated in other studies, in their algorithms because of missing data.

Authors

  • Ting-En Tseng
    Department of Medical Education, National Taiwan University Hospital, Taipei City, Taiwan.
  • Chia-Che Lee
    Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei City, Taiwan.
  • Hung-Kuan Yen
    School of Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
  • Olivier Q Groot
    Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA.
  • Chun-Han Hou
    Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei City, Taiwan.
  • Shin-Ying Lin
    Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei City, Taiwan.
  • Michiel E R Bongers
    Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA.
  • Ming-Hsiao Hu
    Department of Orthopedics, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan. Electronic address: minghsiaohu@yahoo.com.tw.
  • Aditya V Karhade
    Computational Neurosciences Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Jia-Chi Ko
    Department of Medical Education, National Taiwan University Hospital, Taipei City, Taiwan.
  • Yi-Hsiang Lai
    Department of Medical Education, National Taiwan University Hospital, Taipei City, Taiwan.
  • Jing-Jen Yang
    Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei City, Taiwan.
  • Jorrit-Jan Verlaan
    P. T. Ogink, J.-J. Verlaan, Department of Orthopaedic Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Rong-Sen Yang
    Department of Orthopedics, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan.
  • Joseph H Schwab
    Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: jhschwab@mgh.harvard.edu.
  • Wei-Hsin Lin
    Department of Orthopedics, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan.

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