A robotic magnetic resonance-guided high-intensity focused ultrasound platform for neonatal neurosurgery: Assessment of targeting accuracy and precision in a brain phantom.

Journal: Medical physics
Published Date: Mar 1, 2022

Abstract

BACKGROUND: Intraventricular hemorrhage (IVH) is one of the most serious neurovascular complications resulting from premature birth. It can result in clotting of blood within the ventricles, which causes a buildup of cerebrospinal fluid that can lead to posthemorrhagic ventricular dilation and posthemorrhagic hydrocephalus. Currently, there are no direct treatments for these blood clots as the standard of care is invasive surgery to insert a shunt. Magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) has been investigated as a noninvasive treatment to lyse blood clots. However, current MRgHIFU systems are not suitable in the context of treating IVH in neonates.

Authors

  • Hrishikesh Raghuram
    Posluns Centre for Image Guided Innovation and Therapeutic Intervention, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Benjamin Keunen
    The Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
  • Nathan Soucier
    Posluns Centre for Image Guided Innovation and Therapeutic Intervention, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Thomas Looi
    Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada and The Institute of Biomaterials and Biomedical Engineering, The University of Toronto, Toronto, Ontario M5G 3G9, Canada.
  • Samuel Pichardo
    Electrical Engineering, Lakehead University, Thunder Bay, Ontario P7B 5E1, Canada.
  • Adam C Waspe
    Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada and Department of Medical Imaging, The University of Toronto, Toronto, Ontario M5T 1W7, Canada.
  • James M Drake
    Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada; Department of Neurosurgery, The University of Toronto, Toronto, Ontario M5S 1A1, Canada; and The Institute of Biomaterials and Biomedical Engineering, The University of Toronto, Toronto, Ontario M5G 3G9, Canada.

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