Novel indolizine derivatives lowers blood glucose levels in streptozotocin-induced diabetic rats: A histopathological approach.

Journal: Pharmacological reports : PR
Published Date: Nov 28, 2018

Abstract

BACKGROUND: Diabetes mellitus is a deadly disorder in human which induce chronic complications. The streptozotocin (STZ)-induced diabetes in rat is the most common animal model of human diabetes. The present study investigated the effects of novel indolizine derivatives (1-16) on plasma blood glucose concentrations in STZ-diabetic rats.

Authors

  • Vinay Bharadwaj Tatipamula
    Pharmaceutical Chemistry Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, 530 003, Andhra Pradesh, India. Electronic address: tvinaybharadwaj@andhrauniversity.edu.in.
  • Murali Krishna Kolli
    Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, 515 003, Andhra Pradesh, India.
  • Surendra Babu Lagu
    Pharmaceutical Chemistry Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, 530 003, Andhra Pradesh, India.
  • Karuna Raman Paidi
    Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, 515 003, Andhra Pradesh, India.
  • Raveendra Reddy P
    Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, 515 003, Andhra Pradesh, India.
  • Rajendra Prasad Yejella
    Pharmaceutical Chemistry Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, 530 003, Andhra Pradesh, India.

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