Combining Deep Learning and Radiomics for Automated, Objective, Comprehensive Bone Marrow Characterization From Whole-Body MRI: A Multicentric Feasibility Study.

Journal: Investigative radiology
Published Date:

Abstract

OBJECTIVES: Disseminated bone marrow (BM) involvement is frequent in multiple myeloma (MM). Whole-body magnetic resonance imaging (wb-MRI) enables to evaluate the whole BM. Reading of such whole-body scans is time-consuming, and yet radiologists can transfer only a small fraction of the information of the imaging data set to the report. This limits the influence that imaging can have on clinical decision-making and in research toward precision oncology. The objective of this feasibility study was to implement a concept for automatic, comprehensive characterization of the BM from wb-MRI, by automatic BM segmentation and subsequent radiomics analysis of 30 different BM spaces (BMS).

Authors

  • Markus Wennmann
    From the Division of Radiology, German Cancer Research Center (DKFZ).
  • André Klein
    Medical Image Computing, German Cancer Research Center.
  • Fabian Bauer
  • Jiri Chmelik
    Faculty of Electrical Engineering and Communication, Department of Biomedical Engineering, Brno University of Technology, Brno, Technicka 3082/12, 616 00, Czechia. Electronic address: chmelikj@feec.vutbr.cz.
  • Martin Grözinger
    From the Divisions of Radiology.
  • Charlotte Uhlenbrock
  • Jakob Lochner
    From the Divisions of Radiology.
  • Tobias Nonnenmacher
    Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg.
  • Lukas Thomas Rotkopf
    From the Division of Radiology, German Cancer Research Center (DKFZ).
  • Sandra Sauer
    Department of Medicine V, Multiple Myeloma Section, University Hospital Heidelberg.
  • Thomas Hielscher
    Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Michael Götz
    Medical Image Analysis, Division Medical Image Computing, DKFZ Heidelberg, Germany; National Center for Tumor Diseases (NCT), Heidelberg, Germany. Electronic address: m.goetz@dkfz-heidelberg.de.
  • Ralf Omar Floca
  • Peter Neher
    Division of Medical Image Computing (MIC), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Electronic address: p.neher@dkfz.de.
  • David Bonekamp
    From the Department of Radiology (D.B., P.S., J.P.R., P.K., K.Y., M.F., H.P.S.), Division of Medical Image Computing (S.K., M.G., N.G., K.H.M.H.), Division of Statistics (M.W.), and Department of Medical Physics (T.A.K., F.D.), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany (D.B., H.P.S., K.H.M.H.); and Departments of Urology (J.P.R., B.H., M.H., B.A.H.) and Neuroradiology (P.K.), University of Heidelberg Medical Center, Heidelberg, Germany.
  • Jens Hillengass
    Department of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY.
  • Jens Kleesiek
    AG Computational Radiology, Abteilung Radiologie, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Deutschland. j.kleesiek@dkfz-heidelberg.de.
  • Niels Weinhold
    Department of Medicine V, Multiple Myeloma Section, University Hospital Heidelberg.
  • Tim Frederik Weber
    Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg.
  • Hartmut Goldschmidt
  • Stefan Delorme
    From the Divisions of Radiology.
  • Klaus Maier-Hein
    Medical Image Analysis, Division Medical Image Computing, DKFZ Heidelberg, Germany.
  • Heinz-Peter Schlemmer
    From the Department of Radiology (D.B., P.S., J.P.R., P.K., K.Y., M.F., H.P.S.), Division of Medical Image Computing (S.K., M.G., N.G., K.H.M.H.), Division of Statistics (M.W.), and Department of Medical Physics (T.A.K., F.D.), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany (D.B., H.P.S., K.H.M.H.); and Departments of Urology (J.P.R., B.H., M.H., B.A.H.) and Neuroradiology (P.K.), University of Heidelberg Medical Center, Heidelberg, Germany.