Acute myeloid leukemia (AML) is recognized as a highly aggressive cancer that affects the bone marrow and blood, making it the most lethal type of leukemia. The detection of AML through medical imaging is challenging due to the complex structural and...
Environmental stress contributes to the development of depression through neuro-immune interactions, yet the underlying molecular mechanisms and associated clinical diagnostic biomarkers remain unclear. We established a psychosocial stress mouse mode...
Manual diagnosis of hematological cancers like leukemia through bone marrow smear analysis is labor-intensive, prone to errors, and highly dependent on expert knowledge. To overcome these limitations, this study introduces a comprehensive deep learni...
Leukocytes or white blood cells (WBCs) are the main components of the immune system that protect the human body from various infections caused by viruses, bacteria, fungi, and other microorganisms. There are five major types of leukocytes: basophils,...
Leukemia is a hematologic tumor that proliferates in bone marrow and seriously affects the survival of patients. Early and accurate diagnosis is crucial for effective leukemia treatment. Traditional diagnostic methods rely on experts' subjective anal...
BMC medical informatics and decision making
Jul 15, 2025
PURPOSE: Accurate identification of bone marrow invasion (BMI) is critical for determining the prognosis of and treatment strategies for lymphoma. Although bone marrow biopsy (BMB) is the current gold standard, its invasive nature and sampling errors...
Given the graft-versus-leukemia effect observed with allogeneic hematopoietic stem cell transplantation in refractory or relapsed acute myeloid leukemia (AML), immunotherapies have been explored in nontransplant settings. We applied a multiomic appro...
Cytomorphological analysis of the bone marrow aspirate (BMA) is pivotal for the diagnostic workup of a broad range of hematological disorders. However, this skill is error prone, highly complex, and time consuming. Deep learning-based models for the ...
It is well established that the early inflammatory response following fracture is essential for initiating subsequent bone regeneration. An imbalance in inflammation, whether within the innate or adaptive immune response, can result in impaired fract...
Bone marrow (BM) plays a crucial role in the hematopoietic process, producing all of the body's blood cells and maintaining the overall immune and health system. Red and yellow BM are the two various kinds of BM. A comprehensive identification of the...
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