AIMC Topic: Bone Marrow
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An interpretable machine learning model for predicting bone marrow invasion in patients with lymphoma via F-FDG PET/CT: a multicenter study.
BMC medical informatics and decision making
Jul 15, 2025
PURPOSE: Accurate identification of bone marrow invasion (BMI) is critical for determining the prognosis of and treatment strategies for lymphoma. Although bone marrow biopsy (BMB) is the current gold standard, its invasive nature and sampling errors...
Single-cell spatial transcriptomics reveals immunotherapy-driven bone marrow niche remodeling in AML.
Science advances
Jul 9, 2025
Given the graft-versus-leukemia effect observed with allogeneic hematopoietic stem cell transplantation in refractory or relapsed acute myeloid leukemia (AML), immunotherapies have been explored in nontransplant settings. We applied a multiomic appro...
DeepHeme, a high-performance, generalizable deep ensemble for bone marrow morphometry and hematologic diagnosis.
Science translational medicine
Jun 11, 2025
Cytomorphological analysis of the bone marrow aspirate (BMA) is pivotal for the diagnostic workup of a broad range of hematological disorders. However, this skill is error prone, highly complex, and time consuming. Deep learning-based models for the ...
Using artificial intelligence-based software for an unbiased discrimination of immune cell subtypes in the fracture hematoma and bone marrow of non-osteoporotic and osteoporotic mice.
PloS one
Apr 29, 2025
It is well established that the early inflammatory response following fracture is essential for initiating subsequent bone regeneration. An imbalance in inflammation, whether within the innate or adaptive immune response, can result in impaired fract...
Multimodal representations of transfer learning with snake optimization algorithm on bone marrow cell classification using biomedical histopathological images.
Scientific reports
Apr 24, 2025
Bone marrow (BM) plays a crucial role in the hematopoietic process, producing all of the body's blood cells and maintaining the overall immune and health system. Red and yellow BM are the two various kinds of BM. A comprehensive identification of the...
Development and validation of a nomogram for predicting bone marrow involvement in lymphoma patients based on F-FDG PET radiomics and clinical factors.
Annals of nuclear medicine
Mar 29, 2025
OBJECTIVE: This study aimed to develop and validate a nomogram combining F-FDG PET radiomics and clinical factors to non-invasively predict bone marrow involvement (BMI) in patients with lymphoma.
A deep-learning algorithm (AIFORIA) for classification of hematopoietic cells in bone marrow aspirate smears based on nine cell classes-a feasible approach for routine screening?
Journal of hematopathology
Mar 29, 2025
Bone marrow cytology plays a key role for the diagnosis and classification of hematological disease and is often the first step in the acute setting of unclear cytopenia. AI applications represent a powerful tool in digital image analysis and can imp...
Improved MRI detection of inflammation-induced changes in bone marrow microstructure in mice: a machine learning-enhanced T2 distribution analysis.
European radiology experimental
Mar 26, 2025
BACKGROUND: We investigated inflammation-induced changes in femoral hematopoietic bone marrow using advanced magnetic resonance imaging (MRI) techniques, including T2-weighted imaging, scalar T2 mapping, and machine learning-enhanced T2 distribution ...
Statin use and longitudinal bone marrow lesion burden: analysis of knees without osteoarthritis from the Osteoarthritis Initiative study.
Skeletal radiology
Jan 31, 2025
OBJECTIVES: Knee subchondral bone marrow lesions (BMLs) are one of the hallmark features of structural osteoarthritis (OA) and are potential targets for statins' disease-modifying effect. We aimed to determine the association between statin use and l...
Deep learning and genome-wide association meta-analyses of bone marrow adiposity in the UK Biobank.
Nature communications
Jan 2, 2025
Bone marrow adipose tissue is a distinct adipose subtype comprising more than 10% of fat mass in healthy humans. However, the functions and pathophysiological correlates of this tissue are unclear, and its genetic determinants remain unknown. Here, w...
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