Deep learning to diagnose Hashimoto's thyroiditis from sonographic images.

Journal: Nature communications
PMID: 35768466

Abstract

Hashimoto's thyroiditis (HT) is the main cause of hypothyroidism. We develop a deep learning model called HTNet for diagnosis of HT by training on 106,513 thyroid ultrasound images from 17,934 patients and test its performance on 5051 patients from 2 datasets of static images and 1 dataset of video data. HTNet achieves an area under the receiver operating curve (AUC) of 0.905 (95% CI: 0.894 to 0.915), 0.888 (0.836-0.939) and 0.895 (0.862-0.927). HTNet exceeds radiologists' performance on accuracy (83.2% versus 79.8%; binomial test, p < 0.001) and sensitivity (82.6% versus 68.1%; p < 0.001). By integrating serologic markers with imaging data, the performance of HTNet was significantly and marginally improved on the video (AUC, 0.949 versus 0.888; DeLong's test, p = 0.004) and static-image (AUC, 0.914 versus 0.901; p = 0.08) testing sets, respectively. HTNet may be helpful as a tool for the management of HT.

Authors

  • Qiang Zhang
    Yunan Provincial Center for Disease Control and Prevention, Kunming 650022, China.
  • Sheng Zhang
    Department of Critical Care Medicine, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Taizhou, China.
  • Yi Pan
    Department of Neurosis and Psychosomatic Diseases, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, China.
  • Lin Sun
    College of Computer and Information Engineering, Henan Normal University, Xinxiang, China.
  • Jianxin Li
    Department of Ultrasonography, Weihai Municipal Hospital, Shandong, China.
  • Yu Qiao
    Department of English and American Studies, RWTH Aachen University, Aachen, North Rhine-Westphalia, Germany.
  • Jing Zhao
    Department of Pharmacy, Pharmacoepidemiology and Drug Safety Research Group, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
  • Xiaoqing Wang
    Department of Anesthesiology and Operation, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
  • Yixing Feng
    Department of Diagnostic and Therapeutic Ultrasonography, Tianjin's Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
  • Yanhui Zhao
    College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
  • Zhiming Zheng
    Key Laboratory of Mathematics, Informatics and Behavioral Semantics and State Key Laboratory of Software Development Environment, Beihang University, Beijing, China.
  • Xiangming Yang
    Department of Ultrasonography, Dezhou Municiple Hospital, Shandong, China.
  • Lixia Liu
    Department of Ultrasound Room of Functions Branch, Affiliated Hospital of Hebei University, Zhangjiakou, Hebei Province, China.
  • Chunxin Qin
    Department of Thyroid and Breast Surgery, Weihai Municipal Hospital, Shandong, China.
  • Ke Zhao
    Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
  • Xiaonan Liu
    School of Computing, Informatics and Decision Systems Engineering, Arizona State University, Tempe, Arizona.
  • Caixia Li
    Department of Thyroid and Breast Surgery, Tianjin 4th Centre Hospital, Tianjin, China.
  • Liuyang Zhang
    Department of Thyroid Surgery, Affiliated Hospital of Chengde Medical University, Chengde, Hebei Province, China.
  • Chunrui Yang
    Department of Pathology, The Second Hospital of Tianjin Medical University, Tianjin, China.
  • Na Zhuo
    Department of Ultrasonography, The Second Hospital of Tianjin Medical University, Tianjin, China.
  • Hong Zhang
    Department of Anesthesiology and Operation, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
  • Jie Liu
    School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China.
  • Jinglei Gao
    Department of Women and Children Health, School of Public Health of Jilin University, No. 1163 Xinmin Street, Changchun, 130021, China. Electronic address: 13194312508@163.com.
  • Xiaoling Di
    Department of Surgery of Glands, People's Hospital of Dingzhou, Dingzhou, Hebei Province, China.
  • Fanbo Meng
    Department of Thyroid and Breast Surgery, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang Province, China.
  • Linlei Zhang
    Department of General Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
  • Yuxuan Wang
    Department of Maxillofacial and Otorhinolaryngology Oncology, Tianjin's Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
  • Yuansheng Duan
    Department of Maxillofacial and Otorhinolaryngology Oncology, Tianjin's Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
  • Hongru Shen
    Tianjin Cancer Institute, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
  • Yang Li
    Occupation of Chinese Center for Disease Control and Prevention, Beijing, China.
  • Meng Yang
  • Yichen Yang
    The First Clinical Medical College, Lanzhou University, Lanzhou, China.
  • Xiaojie Xin
    Department of Diagnostic and Therapeutic Ultrasonography, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
  • Xi Wei
    Department of Diagnostic and Therapeutic Ultrasonography, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
  • Xuan Zhou
    Clinical Trial Institution, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315100, China.
  • Rui Jin
  • Lun Zhang
    Department of Maxillofacial and Otorhinolaryngology Oncology, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
  • Xudong Wang
    Department of Maxillofacial and Otorhinolaryngology Oncology, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
  • Fengju Song
    Department of Epidemiology and Biostatistics, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Tianjin's Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
  • Xiangqian Zheng
    Department of Ultrasonography, Integrated Traditional Chinese and Western Medicine Hospital, Jilin, China.
  • Ming Gao
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
  • Kexin Chen
    Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
  • Xiangchun Li
    Tianjin Cancer Institute, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.

Keywords

External Resources

Popular Topics
Recent Journals