A Deep Learning Approach to Improve Retinal Structural Predictions and Aid Glaucoma Neuroprotective Clinical Trial Design.

Journal: Ophthalmology. Glaucoma
Published Date:

Abstract

PURPOSE: To investigate the efficacy of a deep learning regression method to predict macula ganglion cell-inner plexiform layer (GCIPL) and optic nerve head (ONH) retinal nerve fiber layer (RNFL) thickness for use in glaucoma neuroprotection clinical trials.

Authors

  • Mark Christopher
    Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, California, United States.
  • Pourya Hoseini
    Department of Computer Science, George Mason University, 4400 University Drive, Fairfax, VA 22030, USA; Center for Advancing Human-Machine Partnerships, George Mason University, 4400 University Drive, Fairfax, VA 22030, USA.
  • Evan Walker
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, California.
  • James A Proudfoot
    Department of Clinical Pharmacy (GJK, GR, AHT), Rady Children's Hospital San Diego, California, Department of Pediatrics (EC, AHT), University of California, San Diego, Clinical and Translational Research Institute (JAP), University of California, San Diego.
  • Christopher Bowd
    Hamilton Glaucoma Center, Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California, San Diego, La Jolla, California.
  • Massimo A Fazio
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama.
  • Christopher A Girkin
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama.
  • Carlos Gustavo De Moraes
    Bernard and Shirlee Brown Glaucoma Research Laboratory, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York.
  • Jeffrey M Liebmann
    Bernard and Shirlee Brown Glaucoma Research Laboratory, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York.
  • Robert N Weinreb
    Hamilton Glaucoma Center, Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California, San Diego, La Jolla, California.
  • Armin Schwartzman
    Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA.
  • Linda M Zangwill
    Hamilton Glaucoma Center, Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California, San Diego, La Jolla, California.
  • Derek S Welsbie
    Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, California. Electronic address: dwelsbie@health.ucsd.edu.