AIMC Topic: Neuroprotection

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From neurotoxicity to neuroprotection: Rethinking GABAR-targeting anesthetics.

Cell biology and toxicology Jun 14, 2025
The brain growth spurt (BGS) represents a pivotal window in neurodevelopment, defined by rapid neurogenesis, heightened synaptogenesis, and the dynamic establishment of neural networks. During this phase, heightened brain plasticity significantly enh...
Brain Animals Oxidative Stress Humans Anesthetics Brain-Derived Neurotrophic Factor Neurotoxicity Syndromes Neuroprotective Agents Receptors, GABA-A Neuroprotection
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Effect of ethanol extract of nigella sativa L seeds and propofol on BDNF protein level as neuroplasticity and neuroprotection of traumatic brain injury in rats.

F1000Research Sep 23, 2024
BACKGROUND: Traumatic brain injury (TBI) is a change in brain function or evidence of brain pathology caused by external mechanical forces. Brain Derived Neurotrophic Factor (BDNF) is a neurotropin that functions as a neuron protective. Nigella sativ...
Ethanol Neuroprotection Rats, Sprague-Dawley Plant Extracts Propofol Neuroprotective Agents Animals Rats Nigella sativa Seeds Male Brain-Derived Neurotrophic Factor Brain Injuries, Traumatic Neuronal Plasticity
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Microglial mediators in autoimmune Uveitis: Bridging neuroprotection and neurotoxicity.

International immunopharmacology May 29, 2024
Autoimmune uveitis, a severe inflammatory condition of the eye, poses significant challenges due to its complex pathophysiology and the critical balance between protective and detrimental immune responses. Central to this balance are microglia, the r...
Uveitis Autoimmune Diseases Animals Neuroprotection Microglia Humans
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A Deep Learning Approach to Improve Retinal Structural Predictions and Aid Glaucoma Neuroprotective Clinical Trial Design.

Ophthalmology. Glaucoma Aug 28, 2022
PURPOSE: To investigate the efficacy of a deep learning regression method to predict macula ganglion cell-inner plexiform layer (GCIPL) and optic nerve head (ONH) retinal nerve fiber layer (RNFL) thickness for use in glaucoma neuroprotection clinical...
Visual Fields Clinical Trials as Topic Intraocular Pressure Deep Learning Neuroprotection Tomography, Optical Coherence Nerve Fibers Retinal Ganglion Cells Humans Glaucoma Cross-Sectional Studies
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Predicting Absorption-Distribution Properties of Neuroprotective Phosphine-Borane Compounds Using In Silico Modeling and Machine Learning.

Molecules (Basel, Switzerland) Apr 25, 2021
Phosphine-borane complexes are novel chemical entities with preclinical efficacy in neuronal and ophthalmic disease models. In vitro and in vivo studies showed that the metabolites of these compounds are capable of cleaving disulfide bonds implicated...
Blood-Brain Barrier Protein Binding Neuroprotective Agents Humans Machine Learning Computer Simulation Neuroprotection Phosphines Boranes
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Virgin Coconut Oil-Induced Neuroprotection in Lipopolysaccharide-Challenged Rats is Mediated, in Part, Through Cholinergic, Anti-Oxidative and Anti-Inflammatory Pathways.

Journal of dietary supplements Oct 14, 2020
Neuroinflammation is associated with neuronal cell death and could lead to chronic neurodegeneration. This study investigated the neuroprotective potential of virgin coconut oil (VCO) against lipopolysaccharide (LPS)-induced cytotoxicity of neuroblas...
Animals Oxidative Stress Rats, Wistar Anti-Inflammatory Agents Acetylcholinesterase Coconut Oil Cholinergic Agents Rats Neuroprotection Lipopolysaccharides
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Evaluation and Identification of the Neuroprotective Compounds of Xiaoxuming Decoction by Machine Learning: A Novel Mode to Explore the Combination Rules in Traditional Chinese Medicine Prescription.

BioMed research international Jul 10, 2019
Xiaoxuming decoction (XXMD), a classic traditional Chinese medicine (TCM) prescription, has been used as a therapeutic in the treatment of stroke in clinical practice for over 1200 years. However, the pharmacological mechanisms of XXMD have not yet b...
Drugs, Chinese Herbal Bayes Theorem Stroke Hydrogen Peroxide Medicine, Chinese Traditional Neuroprotection Humans Machine Learning Algorithms Brain
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Neuroprotective role of 6-Gingerol-rich fraction of Zingiber officinale (Ginger) against acrylonitrile-induced neurotoxicity in male Wistar rats.

Journal of basic and clinical physiology and pharmacology Dec 22, 2018
Background Acrylonitrile (AN) is a neurotoxin that is widely used to manufacture synthetic fibres, plastics and beverage containers. Recently, we reported the ameliorative role of 6-gingerol-rich fraction from Zingiber officinale (Ginger, GRF) on the...
Glutathione Transferase Antioxidants Plant Extracts Glutathione Peroxidase Rats, Wistar Animals Catalase Rats Glutathione Cerebral Cortex Male Tumor Necrosis Factor-alpha Lipid Peroxidation Nitric Oxide Acrylonitrile Superoxide Dismutase Fatty Alcohols Oxidative Stress Interleukin-6 Catechols Malondialdehyde Inflammation Zingiber officinale Neuroprotection
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