Prenatal exposure to persistent organic pollutants in Northern Tanzania and their distribution between breast milk, maternal blood, placenta and cord blood.

Journal: Environmental research
PMID: 30634139

Abstract

Human exposure to persistent organic pollutants (POPs) begins during pregnancy and may cause adverse health effects in the fetus or later in life. The present study aimed to assess prenatal POPs exposure to Tanzanian infants and evaluate the distribution of POPs between breast milk, maternal blood, placenta and cord blood. For assessment of prenatal exposure, 48 maternal blood samples from Mount Meru Regional Referral Hospital (MMRRH), Arusha Tanzania, were analyzed for organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), brominated flame retardants (BFRs), dioxin-like (DL) activity and perfluorinated alkyl substances (PFASs). For evaluation of POPs distribution between maternal/infant compartments, breast milk, placenta and cord blood corresponding to the maternal blood were analyzed for OCPs, PCBs and BFRs. In maternal blood, p,p´- DDE was detected in 100% of the samples ranging between 29 and 1890 ng/g lipid weight (lw). PCB-153 was the only PCB detected in maternal blood, with detection rate of 29% and concentrations up to 116 ng/g lw. BDE-47 was detected in 65% of the maternal blood samples, ranging between

Authors

  • M H B Müller
    Norwegian University of Life Sciences, Campus Adamstuen, P.O. Box 8146 Dep, N-0033 Oslo, Norway. Electronic address: mette.helen.bjorge.muller@nmbu.no.
  • A Polder
    Norwegian University of Life Sciences, Campus Adamstuen, P.O. Box 8146 Dep, N-0033 Oslo, Norway.
  • O B Brynildsrud
    Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo, Norway.
  • R Grønnestad
    Norwegian University of Life Sciences, Campus Adamstuen, P.O. Box 8146 Dep, N-0033 Oslo, Norway; Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.
  • M Karimi
    Norwegian University of Life Sciences, Campus Adamstuen, P.O. Box 8146 Dep, N-0033 Oslo, Norway.
  • E Lie
    Norwegian University of Life Sciences, Campus Adamstuen, P.O. Box 8146 Dep, N-0033 Oslo, Norway; Norwegian Institute for Water Research, Gaustadallèen 21, N-0349 Oslo, Norway.
  • W B Manyilizu
    Sokoine University of Agriculture, Department of Veterinary Medicine and Public Health, P.O. Box 3021, Morogoro, Tanzania.
  • R H Mdegela
    Sokoine University of Agriculture, Department of Veterinary Medicine and Public Health, P.O. Box 3021, Morogoro, Tanzania.
  • F Mokiti
    Mount Meru Regional Referral Hospital, P.O. Box 3092, Arusha, Tanzania.
  • M Murtadha
    Mount Meru Regional Referral Hospital, P.O. Box 3092, Arusha, Tanzania.
  • H E Nonga
    Sokoine University of Agriculture, Department of Veterinary Medicine and Public Health, P.O. Box 3021, Morogoro, Tanzania.
  • J U Skaare
    Norwegian Veterinary Institute, P.O. Box 750 Sentrum, N-0106 Oslo, Norway.
  • A Solhaug
    Norwegian Veterinary Institute, P.O. Box 750 Sentrum, N-0106 Oslo, Norway.
  • J L Lyche
    Norwegian University of Life Sciences, Campus Adamstuen, P.O. Box 8146 Dep, N-0033 Oslo, Norway.

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