AIMC Topic: Milk, Human
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Identification of nanoparticle infiltration in human breast milk: Chemical profiles and trajectory pathways.
Proceedings of the National Academy of Sciences of the United States of America
May 12, 2025
Breast milk is crucial for infant health, offering essential nutrients and immune protection. However, despite increasing exposure risks from nanoparticles (NPs), their potential infiltration into human breast milk remains poorly understood. This stu...
Machine learning approaches for assessing medication transfer to human breast milk.
Journal of pharmacokinetics and pharmacodynamics
Apr 16, 2025
The human milk/plasma (M/P) drug concentration ratio is crucial in pharmacology, especially for breastfeeding mothers undergoing treatment. It determines the extent to which drugs ingested by the mother pass into breast milk, potentially affecting th...
Immunological composition of human milk before and during subclinical and clinical mastitis.
Frontiers in immunology
Jan 17, 2025
Mastitis, an inflammatory condition affecting more than 25% of breastfeeding women, is usually associated with reduced milk secretion, pain, and discomfort, which often leads to early cessation of breastfeeding. Although the etiology of mastitis is m...
Assessing chemical exposure risk in breastfeeding infants: An explainable machine learning model for human milk transfer prediction.
Ecotoxicology and environmental safety
Jan 11, 2025
Breast milk is essential for infant health, but the transfer of xenobiotic chemicals poses significant risks. Ethical challenges in clinical trials necessitate the use of in vitro predictive models to assess chemical exposure risks in breastfeeding i...
Artificial intelligence applied to the study of human milk and breastfeeding: a scoping review.
International breastfeeding journal
Dec 6, 2024
BACKGROUND: Breastfeeding rates remain below the globally recommended levels, a situation associated with higher infant and neonatal mortality rates. The implementation of artificial intelligence (AI) could help improve and increase breastfeeding rat...
Cohort profile: Japanese human milk study, a prospective birth cohort: baseline data for lactating women, infants and human milk macronutrients.
BMJ open
Dec 30, 2021
PURPOSE: The Japanese Human Milk Study, a longitudinal prospective cohort study, was set up to clarify how maternal health, nutritional status, lifestyle and sociodemographic and economic factors affect breastfeeding practices and human milk composit...
Human breast milk-based nutritherapy: A blueprint for pediatric healthcare.
Journal of food and drug analysis
Jun 15, 2021
Human Breast Milk (HBM) is a storehouse of micronutrients, macronutrients, immune factors, microbiota and numerous other bioactive macromolecules. Fulfilment of optimum nutritional requirements of more than 240 million malnourished infants worldwide ...
Prenatal exposure to persistent organic pollutants in Northern Tanzania and their distribution between breast milk, maternal blood, placenta and cord blood.
Environmental research
Dec 18, 2018
Human exposure to persistent organic pollutants (POPs) begins during pregnancy and may cause adverse health effects in the fetus or later in life. The present study aimed to assess prenatal POPs exposure to Tanzanian infants and evaluate the distribu...
Simultaneous quantification of fluoxetine and norfluoxetine in colostrum and mature human milk using a 2-dimensional liquid chromatography-tandem mass spectrometry system.
Journal of pharmaceutical and biomedical analysis
Dec 20, 2017
A two-dimensional liquid chromatography system coupled to triple quadrupole tandem mass spectrometer (2D LC-MS/MS) was employed for the determination of fluoxetine (FLU) and norfluoxetine (N-FLU) in colostrum and mature milk by direct sample injectio...
Simultaneous LC-MS/MS determination of 40 legal and illegal psychoactive drugs in breast and bovine milk.
Food chemistry
Oct 10, 2017
This work presents a fast, sensitive and reliable multi-residue methodology based on fat and protein precipitation and liquid chromatography-tandem mass spectrometry for the determination of common legal and illegal psychoactive drugs, and major meta...
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