NAVIGATOR: an Italian regional imaging biobank to promote precision medicine for oncologic patients.

Journal: European radiology experimental
PMID: 36344838

Abstract

NAVIGATOR is an Italian regional project boosting precision medicine in oncology with the aim of making it more predictive, preventive, and personalised by advancing translational research based on quantitative imaging and integrative omics analyses. The project's goal is to develop an open imaging biobank for the collection and preservation of a large amount of standardised imaging multimodal datasets, including computed tomography, magnetic resonance imaging, and positron emission tomography data, together with the corresponding patient-related and omics-related relevant information extracted from regional healthcare services using an adapted privacy-preserving model. The project is based on an open-source imaging biobank and an open-science oriented virtual research environment (VRE). Available integrative omics and multi-imaging data of three use cases (prostate cancer, rectal cancer, and gastric cancer) will be collected. All data confined in NAVIGATOR (i.e., standard and novel imaging biomarkers, non-imaging data, health agency data) will be used to create a digital patient model, to support the reliable prediction of the disease phenotype and risk stratification. The VRE that relies on a well-established infrastructure, called D4Science.org, will further provide a multiset infrastructure for processing the integrative omics data, extracting specific radiomic signatures, and for identification and testing of novel imaging biomarkers through big data analytics and artificial intelligence.

Authors

  • Rita Borgheresi
    Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa, 56126, Pisa, Italy.
  • Andrea Barucci
    Institute of Applied Physics "Nello Carrara", Italian National Research Council, via Madonna del Piano 10, Sesto Fiorentino, I-50019, Italy. p.matteini@ifac.cnr.it.
  • Sara Colantonio
    Institute of Information Science and Technologies - ISTI of the National Research Council - CNR, Pisa, Italy.
  • Gayane Aghakhanyan
    Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa, 56126, Pisa, Italy. gayane.aghakhanyan@med.unipi.it.
  • Massimiliano Assante
    Institute of Information Science and Technologies - ISTI of the National Research Council - CNR, Pisa, Italy.
  • Elena Bertelli
    Department of Radiology, Careggi University Hospital, Florence, Italy.
  • Emanuele Carlini
    Institute of Information Science and Technologies - ISTI of the National Research Council - CNR, Pisa, Italy.
  • Roberto Carpi
    Azienda USL Toscana Centro, Florence, Italy.
  • Claudia Caudai
    Institute of Information Science and Technologies - ISTI of the National Research Council - CNR, Pisa, Italy.
  • Diletta Cavallero
    Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa, 56126, Pisa, Italy.
  • Dania Cioni
    Academic Radiology, Department of Surgical, Medical, Molecular Pathology and Emergency Medicine, University of Pisa, Via Roma 67, 56126, Pisa, Italy.
  • Roberto Cirillo
    Institute of Information Science and Technologies - ISTI of the National Research Council - CNR, Pisa, Italy.
  • Valentina Colcelli
    "Nello Carrara" Institute of Applied Physics - IFAC of the National Research Council - CNR, Florence, Italy.
  • Andrea Dell'Amico
    Institute of Information Science and Technologies - ISTI of the National Research Council - CNR, Pisa, Italy.
  • Domnico Di Gangi
    Institute of Information Science and Technologies - ISTI of the National Research Council - CNR, Pisa, Italy.
  • Paola Anna Erba
    Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa, 56126, Pisa, Italy.
  • Lorenzo Faggioni
    Diagnostic and Interventional Radiology, Department of Translational Research, University of Pisa, Via Roma, 67, 56126, Pisa, Italy. lfaggioni@sirm.org.
  • Zeno Falaschi
    Department of Radiology, A.O.U, "Maggiore d.c." Universiy of Eastern Piedmont, Novara, Italy.
  • Michela Gabelloni
    Academic Radiology, Department of Translational Research, University of Pisa, Via Roma 67, 56126, Pisa, Italy.
  • Rosa Gini
    Azienda Regionale di Sanità, Florence, Italy.
  • Lucio Lelii
    Institute of Information Science and Technologies - ISTI of the National Research Council - CNR, Pisa, Italy.
  • Pietro Lió
    Computer Laboratory, University of Cambridge, 15 JJ Thomson Avenue, Cambridge, UK.
  • Antonio Lorito
    "Nello Carrara" Institute of Applied Physics - IFAC of the National Research Council - CNR, Florence, Italy.
  • Silvia Lucarini
    Department of Radiology, Careggi University Hospital, Florence, Italy.
  • Paolo Manghi
    Institute of Information Science and Technologies - ISTI of the National Research Council - CNR, Pisa, Italy.
  • Francesco Mangiacrapa
    Institute of Information Science and Technologies - ISTI of the National Research Council - CNR, Pisa, Italy.
  • Chiara Marzi
    Department of Electrical, Electronic, and Information Engineering 'Guglielmo Marconi', University of Bologna, Cesena, Italy.
  • Maria Antonietta Mazzei
    Unit of Diagnostic Imaging, Department of Medical, Surgical and Neurosciences and of Radiological Sciences, University of Siena, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.
  • Laura Mercatelli
    Department of Radiology, Careggi University Hospital, Florence, Italy.
  • Antonella Mirabile
    "Nello Carrara" Institute of Applied Physics - IFAC of the National Research Council - CNR, Florence, Italy.
  • Francesco Mungai
    Department of Radiology, Careggi University Hospital, Florence, Italy.
  • Vittorio Miele
    Department of Radiology, Careggi University Hospital, L.go G.A. Brambilla, 3, 50134, Florence, Italy. vmiele@sirm.org.
  • Maristella Olmastroni
    Azienda USL Toscana Centro, Florence, Italy.
  • Pasquale Pagano
    Institute of Information Science and Technologies - ISTI of the National Research Council - CNR, Pisa, Italy.
  • Fabiola Paiar
    Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa, 56126, Pisa, Italy.
  • Giancarlo Panichi
    Institute of Information Science and Technologies - ISTI of the National Research Council - CNR, Pisa, Italy.
  • Maria Antonietta Pascali
    Institute of Information Science and Technologies - ISTI of the National Research Council - CNR, Pisa, Italy.
  • Filippo Pasquinelli
    Azienda USL Toscana Centro, Florence, Italy.
  • Jorge Eduardo Shortrede
    Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa, 56126, Pisa, Italy.
  • Lorenzo Tumminello
    Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa, 56126, Pisa, Italy.
  • Luca Volterrani
    Unit of Diagnostic Imaging, Department of Medical, Surgical and Neurosciences and of Radiological Sciences, University of Siena, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.
  • Emanuele Neri
    Department of Radiological Sciences, University of Pisa, Via Savi 10, 56126 Pisa, Italy.

Keywords

External Resources

Popular Topics
Recent Journals