Assess the documentation of cognitive tests and biomarkers in electronic health records via natural language processing for Alzheimer's disease and related dementias.

Journal: International journal of medical informatics
PMID: 36577203

Abstract

BACKGROUND: Cognitive tests and biomarkers are the key information to assess the severity and track the progression of Alzheimer's' disease (AD) and AD-related dementias (AD/ADRD), yet, both are often only documented in clinical narratives of patients' electronic health records (EHRs). In this work, we aim to (1) assess the documentation of cognitive tests and biomarkers in EHRs that can be used as real-world endpoints, and (2) identify, extract, and harmonize the different commonly used cognitive tests from clinical narratives using natural language processing (NLP) methods into categorical AD/ADRD severity.

Authors

  • Zhaoyi Chen
    Department of Epidemiology, College of Medicine & College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
  • Hansi Zhang
    Health Outcomes & Biomedical Informatics, College of Medicine, University of Florida, 2004 Mowry Road, Gainesville, FL, 32610, USA.
  • Xi Yang
    Department of Health Outcomes and Biomedical Informatics.
  • Songzi Wu
    Department of Health Outcomes and Biomedical Informatics.
  • Xing He
    University of Florida, Gainesville, Florida, USA.
  • Jie Xu
    Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang Province 310000, China.
  • Jingchuan Guo
    Department of Pharmaceutical Outcomes and Policy, University of Florida, Gainesville, FL.
  • Mattia Prosperi
    University of Florida, Gainesville, Florida, USA.
  • Fei Wang
    Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, NY, United States.
  • Hua Xu
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Yong Chen
    Department of Urology, Chongqing University Fuling Hospital, Chongqing, China.
  • Hui Hu
    Department of Epidemiology, College of Medicine & College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
  • Steven T DeKosky
    Department of Neurology, University of Florida, Gainesville, FL, USA.
  • Matthew Farrer
    Department of Neurology, University of Florida, Gainesville, FL, USA.
  • Yi Guo
    Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Yonghui Wu
    Department of Health Outcomes and Biomedical Informatics.
  • Jiang Bian
    Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida, United States of America.

Keywords

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