Antiphospholipid Antibodies and Heart Valve Disease in Systemic Lupus Erythematosus.
Journal:
The American journal of the medical sciences
PMID:
29549933
Abstract
Evaluation of antiphospholipid antibodies (aPL) and correlation with heart valve abnormalities among patients with systemic lupus erythematosus (SLE). Nested case-control study was conducted with 70 patients with SLE selected from a longitudinal database based on levels of aPL and presence or absence of valve disease by echocardiogram. Valvular abnormalities observed were regurgitation (52), other (14), artificial valves (4), stenosis (2), thickening (2) and no Libman-Sacks endocarditis (0). The mitral valve was the most commonly affected (30 abnormalities), followed by the tricuspid (20 abnormalities). Multivariate logistic regression for those with and without an aPL value ≥20 units/mL, adjusted for disease duration and age, showed significant differences for any valve abnormality (odds ratio [OR] = 3.1; 95% CI: 1.0-8.9; P = 0.041) and individually for the tricuspid valve (OR = 3.3; 95% CI: 1.0-11.1; P = 0.052) but not for the mitral valve (OR = 2.1; 95% CI: 0.68-6.45; P = 0.195). Levels of aPL ≥20 units/mL showed no association with aortic (P = 0.253), pulmonic (P = 1.000), tricuspid (P = 0.127), or mitral (P = 0.249) valve abnormalities. Levels of aPL correlate with certain valvular abnormalities among patients with SLE.
Authors
Keywords
Adolescent
Adult
Antibodies, Antiphospholipid
Aortic Valve Insufficiency
Aortic Valve Stenosis
Case-Control Studies
Echocardiography
Female
Heart Valve Diseases
Heart Valve Prosthesis
Humans
Logistic Models
Lupus Erythematosus, Systemic
Male
Middle Aged
Mitral Valve Insufficiency
Mitral Valve Stenosis
Multivariate Analysis
Odds Ratio
Tricuspid Valve Insufficiency
Young Adult