Discriminating and understanding brain states in children with epileptic spasms using deep learning and graph metrics analysis of brain connectivity.

Journal: Computer methods and programs in biomedicine
PMID:

Abstract

BACKGROUND AND OBJECTIVE: Epilepsy is a brain disorder consisting of abnormal electrical discharges of neurons resulting in epileptic seizures. The nature and spatial distribution of these electrical signals make epilepsy a field for the analysis of brain connectivity using artificial intelligence and network analysis techniques since their study requires large amounts of data over large spatial and temporal scales. For example, to discriminate states that would otherwise be indistinguishable from the human eye. This paper aims to identify the different brain states that appear concerning the intriguing seizure type of epileptic spasms. Once these states have been differentiated, an attempt is made to understand their corresponding brain activity.

Authors

  • Alberto Nogales
    CEIEC, Research Institute, Universidad Francisco de Vitoria, Ctra. M-515 Pozuelo-Majadahonda km 1800, 28223, Pozuelo de Alarcón, Spain. Electronic address: alberto.nogales@ceiec.es.
  • Álvaro J García-Tejedor
    CEIEC, Research Institute, Universidad Francisco de Vitoria, Ctra. M-515 Pozuelo-Majadahonda km 1800, 28223, Pozuelo de Alarcón, Spain. Electronic address: a.gtejedor@ceiec.es.
  • Pedro Chazarra
    CEIEC Research Institute, Universidad Francisco de Vitoria, Ctra. M-515 Pozuelo-Majadahonda km. 1,800, Pozuelo de Alarcón 28223, Spain.
  • Arturo Ugalde-Canitrot
    School of Medicine. Universidad Francisco de Vitoria, Ctra. M-515 Pozuelo-Majadahonda km. 1,800. Pozuelo de Alarcón 28223, Spain; Epilepsy Unit, Neurology and Clinical Neurophysiology Service, Hospital Universitario La Paz, Paseo de la Castellana, 261, Madrid 28046, Spain.