Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets.

Journal: Frontiers in immunology
PMID: 39877357

Abstract

BACKGROUND: Type 2 Diabetes Mellitus (T2DM) represents a major global health challenge, marked by chronic hyperglycemia, insulin resistance, and immune system dysfunction. Immune cells, including T cells and monocytes, play a pivotal role in driving systemic inflammation in T2DM; however, the underlying single-cell mechanisms remain inadequately defined.

Authors

  • Huahua Li
    Department of Geriatric, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China.
  • Lingling Zou
    Department of Geriatric, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China.
  • Zhaowei Long
    Department of Geriatric, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
  • Junkun Zhan
    Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China.

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