Optimization of anastomotic technique and gastric conduit perfusion with hyperspectral imaging and machine learning in an experimental model for minimally invasive esophagectomy.

Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
PMID:

Abstract

INTRODUCTION: Esophagectomy is the mainstay of esophageal cancer treatment, but anastomotic insufficiency related morbidity and mortality remain challenging for patient outcome. Therefore, the objective of this work was to optimize anastomotic technique and gastric conduit perfusion with hyperspectral imaging (HSI) for total minimally invasive esophagectomy (MIE) with linear stapled anastomosis.

Authors

  • F Nickel
    Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 420, 69120, Heidelberg, Deutschland.
  • A Studier-Fischer
    Department of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany; School of Medicine, Heidelberg University, Heidelberg, Germany.
  • B Özdemir
    Department of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • J Odenthal
    Department of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • L R Müller
    HIDSS4Health - Helmholtz Information and Data Science School for Health, Heidelberg and Karlsruhe, Germany; Division of Computer Assisted Medical Interventions, German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Mathematics and Computer Science, Heidelberg University, Heidelberg, Germany.
  • S Knoedler
    Department of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • K F Kowalewski
    Department of Urology, Medical Faculty of Mannheim at the University of Heidelberg, Mannheim, Germany.
  • I Camplisson
    Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, USA.
  • M M Allers
    Department of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • M Dietrich
    Department of Anaesthesiology, Heidelberg University Hospital, Heidelberg, Germany.
  • K Schmidt
    Department of Anaesthesiology and Intensive Care Medicine, Essen University Hospital, Essen, Germany.
  • G A Salg
    Department of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • H G Kenngott
    Department of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • A T Billeter
    Department of General, Visceral, and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • I Gockel
    Department of Visceral, Transplantation, Thoracic and Vascular Surgery, Leipzig University Hospital, Leipzig, Germany.
  • C Sagiv
    DeePathology Ltd., Ra'anana, Israel.
  • O E Hadar
    DeePathology Ltd., Ra'anana, Israel.
  • J Gildenblat
    DeePathology Ltd., Ra'anana, Israel.
  • L Ayala
    HIDSS4Health - Helmholtz Information and Data Science School for Health, Heidelberg and Karlsruhe, Germany; Division of Computer Assisted Medical Interventions, German Cancer Research Center (DKFZ), Heidelberg, Germany; Medical Faculty, Heidelberg University, Heidelberg, Germany.
  • S Seidlitz
    HIDSS4Health - Helmholtz Information and Data Science School for Health, Heidelberg and Karlsruhe, Germany; Division of Computer Assisted Medical Interventions, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • L Maier-Hein
    Abteilung für computer-assistierte medizinische Interventionen, Deutsches Krebsforschungszentrum Heidelberg, Im Neuenheimer Feld 223, 69120, Heidelberg, Deutschland.
  • B P Müller-Stich
    Department for General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany. beatpeter.mueller@med.uni-heidelberg.de.