Predicting benefit from immune checkpoint inhibitors in patients with non-small-cell lung cancer by CT-based ensemble deep learning: a retrospective study.

Journal: The Lancet. Digital health
Published Date: Jul 1, 2023

Abstract

BACKGROUND: Only around 20-30% of patients with non-small-cell lung cancer (NCSLC) have durable benefit from immune-checkpoint inhibitors. Although tissue-based biomarkers (eg, PD-L1) are limited by suboptimal performance, tissue availability, and tumour heterogeneity, radiographic images might holistically capture the underlying cancer biology. We aimed to investigate the application of deep learning on chest CT scans to derive an imaging signature of response to immune checkpoint inhibitors and evaluate its added value in the clinical context.

Authors

  • Maliazurina B Saad
    Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Lingzhi Hong
    Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Muhammad Aminu
    Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Natalie I Vokes
    Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Pingjun Chen
    J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States.
  • Morteza Salehjahromi
    Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Kang Qin
    Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Sheeba J Sujit
    Department of Diagnostic and Interventional Imaging, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.
  • Xuetao Lu
    Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Elliana Young
    Department of Enterprise Data Engineering and Analytics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Qasem Al-Tashi
    Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Rizwan Qureshi
    Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Carol C Wu
    University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Brett W Carter
    Department of Thoracic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Steven H Lin
  • Percy P Lee
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Radiation Oncology, City of Hope National Medical Center, Los Angeles, CA, USA.
  • Saumil Gandhi
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Joe Y Chang
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Ruijiang Li
    Global Station for Quantum Medical Science and Engineering, Global Institution for Collaborative Research and Education (GI-CoRE), Proton Beam Therapy Center, North 14 West 5 Kita-ku, Sapporo, Hokkaido, 060-8648, Japan.
  • Michael F Gensheimer
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
  • Heather A Wakelee
    Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cancer Institute, Stanford, CA, USA.
  • Joel W Neal
    Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cancer Institute, Stanford, CA, USA.
  • Hyun-Sung Lee
    Systems Onco-Immunology Laboratory, David J Sugarbaker Division of Thoracic Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
  • Chao Cheng
    Department of Molecular and Systems Biology, Lebanon, USA. Chao.Cheng@bcm.edu.
  • Vamsidhar Velcheti
    Department of Biomedical Engineering, Case Western Reserve University School of Engineering, 2071 Martin Luther King Dr, Cleveland, OH 44106-7207 (M. Khorrami, K.B., A.M.); Departments of Internal Medicine (M. Khunger) and Solid Tumor Oncology (A.Z., P.P.), Cleveland Clinic, Cleveland, Ohio; Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio (P.F.); Department of Hematology and Oncology, New York University, New York, NY (V.V.); Louis Stokes Cleveland Veterans Administration Medical Center, Cleveland, Ohio (A.M.).
  • Yanyan Lou
    Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USA.
  • Milena Petranovic
    Department of Radiology, Massachusetts General Brigham and Harvard Medical School, Boston, MA, USA.
  • Waree Rinsurongkawong
    Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Xiuning Le
    Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Vadeerat Rinsurongkawong
    Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Amy Spelman
    Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Yasir Y Elamin
    Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Marcelo V Negrao
    Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Ferdinandos Skoulidis
    Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Carl M Gay
    Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Tina Cascone
    Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, Texas, USA.
  • Mara B Antonoff
    Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: mbantonoff@mdanderson.org.
  • Boris Sepesi
    Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Jeff Lewis
    Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Ignacio I Wistuba
    Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX.
  • John D Hazle
    Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
  • Caroline Chung
    The University of Texas MD Anderson Cancer Center, Houston, TX.
  • David Jaffray
    Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada.
  • Don L Gibbons
    Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Ara Vaporciyan
    Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • J Jack Lee
    Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • John V Heymach
    Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Jianjun Zhang
    Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, Texas, USA.
  • Jia Wu

Keywords

External Resources

Popular Topics
Recent Journals