Self-Propelled Janus Nanocatalytic Robots Guided by Magnetic Resonance Imaging for Enhanced Tumor Penetration and Therapy.

Journal: Journal of the American Chemical Society
PMID: 37190936

Abstract

Biomedical micro/nanorobots as active delivery systems with the features of self-propulsion and controllable navigation have made tremendous progress in disease therapy and diagnosis, detection, and biodetoxification. However, existing micro/nanorobots are still suffering from complex drug loading, physiological drug stability, and uncontrollable drug release. To solve these problems, micro/nanorobots and nanocatalytic medicine as two independent research fields were integrated in this study to achieve self-propulsion-induced deeper tumor penetration and catalytic reaction-initiated tumor therapy in vivo. We presented self-propelled Janus nanocatalytic robots (JNCRs) guided by magnetic resonance imaging (MRI) for in vivo enhanced tumor therapy. These JNCRs exhibited active movement in HO solution, and their migration in the tumor tissue could be tracked by non-invasive MRI in real time. Both increased temperature and reactive oxygen species production were induced by near-infrared light irradiation and iron-mediated Fenton reaction, showing great potential for tumor photothermal and chemodynamic therapy. In comparison with passive nanoparticles, these self-propelled JNCRs enabled deeper tumor penetration and enhanced tumor therapy after intratumoral injection. Importantly, these robots with biocompatible components and byproducts exhibited biosecurity in the mouse model. It is expected that our work could promote the combination of micro/nanorobots and nanocatalytic medicine, resulting in improved tumor therapy and potential clinical transformations.

Authors

  • Zhaoli Sun
    Beijing Key Laboratory for Magnetoelectric Materials and Devices (BKL-MMD), School of Materials Science and Engineering, Peking University, Beijing 100871, China.
  • Tao Wang
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Jingjing Wang
    Department of Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, China; School of Medicine, South China University of Technology, Guangzhou, Guangdong Province, China.
  • Junjie Xu
    Beijing Institute of Biotechnology, 20 Dongdajie Street, Fengtai District, Beijing, China.
  • Tong Shen
    Beijing Key Laboratory for Magnetoelectric Materials and Devices (BKL-MMD), School of Materials Science and Engineering, Peking University, Beijing 100871, China.
  • Teng Zhang
    College of Veterinary Medicine, Hebei Agricultural University, Baoding, Hebei 071000, China.
  • Biao Zhang
    Heilongjiang Provincial Key Laboratory of Complex Intelligent System and Integration, School of Automation, Harbin University of Science and Technology, Harbin 150080, China.
  • Shen Gao
    Department of Radiology, the Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
  • Chenyang Zhao
    SILC Business School, Shanghai University, Shanghai 201800, China.
  • Meng Yang
  • Fugeng Sheng
    Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
  • Jing Yu
    Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Yanglong Hou
    Beijing Key Laboratory for Magnetoelectric Materials and Devices (BKL-MMD), School of Materials Science and Engineering, Peking University, Beijing 100871, China.

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