Deep learning-based scoring of tumour-infiltrating lymphocytes is prognostic in primary melanoma and predictive to PD-1 checkpoint inhibition in melanoma metastases.

Abstract

Authors

• Eftychia Chatziioannou
  Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", Tübingen, Germany.
• Jana Roßner
  Department of Dermatology, University of Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, Germany.
• Thazin New Aung
  Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
• David L Rimm
  Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
• Heike Niessner
  Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", Tübingen, Germany.
• Ulrike Keim
  Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, Germany.
• Lina Maria Serna-Higuita
  Department of Clinical Epidemiology and Applied Biostatistics, Eberhard Karls University of Tübingen, 72076 Tübingen, Germany.
• Irina Bonzheim
  Institute of Pathology and Neuropathology, Eberhard Karls University of Tübingen, 72076 Tübingen, Germany.
• Luis Kuhn Cuellar
  Quantitative Biology Center (QBiC), University of Tübingen, Tübingen, Germany.
• Dana Westphal
  Department of Dermatology, Faculty of Medicine and University Hospital Carl Gustav Carus, Skin Cancer Center at the University Cancer Center and National Center for Tumor Diseases, Technical University Dresden, 01307 Dresden, Germany.
• Julian Steininger
  Department of Dermatology, Faculty of Medicine and University Hospital Carl Gustav Carus, Skin Cancer Center at the University Cancer Center and National Center for Tumor Diseases, Technical University Dresden, 01307 Dresden, Germany.
• Friedegund Meier
  Skin Cancer Center at the University Cancer Centre and National Center for Tumor Diseases Dresden, Department of Dermatology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.
• Oltin Tiberiu Pop
  Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
• Stephan Forchhammer
  Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, Germany.
• Lukas Flatz
  Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, Germany; Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
• Thomas Eigentler
  Center of Dermatooncology, Department of Dermatology, Eberhard Karls Universitat Tubingen, Tubingen, Germany.
• Claus Garbe
  Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, Germany.
• Martin Röcken
  Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", Tübingen, Germany.
• Teresa Amaral
  Center of Dermatooncology, Department of Dermatology, Eberhard Karls Universitat Tubingen, Tubingen, Germany.
• Tobias Sinnberg
  Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", Tübingen, Germany; Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: tobias.sinnberg@med.uni-tuebingen.de.

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