Consistency in contouring of organs at risk by artificial intelligence vs oncologists in head and neck cancer patients.

Journal: Acta oncologica (Stockholm, Sweden)
Published Date: Nov 1, 2023

Abstract

BACKGROUND: In the Danish Head and Neck Cancer Group (DAHANCA) 35 trial, patients are selected for proton treatment based on simulated reductions of Normal Tissue Complication Probability (NTCP) for proton compared to photon treatment at the referring departments. After inclusion in the trial, immobilization, scanning, contouring and planning are repeated at the national proton centre. The new contours could result in reduced expected NTCP gain of the proton plan, resulting in a loss of validity in the selection process. The present study evaluates if contour consistency can be improved by having access to AI (Artificial Intelligence) based contours.

Authors

  • Camilla Panduro Nielsen
    Laboratory of Radiation Physics, Odense University Hospital, Odense, Denmark.
  • Ebbe Laugaard Lorenzen
    Laboratory of Radiation Physics, Department of Oncology, Odense University Hospital, Odense, Denmark.
  • Kenneth Jensen
    Danish Centre of Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
  • Nis Sarup
    Laboratory of Radiation Physics, Odense University Hospital, Odense, Denmark.
  • Carsten Brink
    Laboratory of Radiation Physics, Odense University Hospital, Odense, Denmark.
  • Bob Smulders
    Danish Centre of Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
  • Anne Ivalu Sander Holm
    Department of Oncology, Aarhus University Hospital, Aarhus N, Denmark.
  • Eva Samsøe
    Danish Centre of Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
  • Martin Skovmos Nielsen
    Department of Oncology, Aalborg University Hospital, Aalborg, Denmark.
  • Patrik Sibolt
    Department of Oncology, Herlev & Gentofte Hospital, Herlev, Denmark.
  • Peter Sandegaard Skyt
    Danish Centre of Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
  • Ulrik Vindelev Elstrøm
    Danish Centre of Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
  • Jørgen Johansen
    Department of Oncology, Odense University Hospital, Odense, Denmark.
  • Ruta Zukauskaite
    Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
  • Jesper Grau Eriksen
    Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Mohammad Farhadi
    Department of Oncology, Zealand University Hospital, Naestved, Denmark.
  • Maria Andersen
    Department of Oncology, Aalborg University Hospital, Aalborg, Denmark.
  • Christian Maare
    Department of Oncology, University Hospital Herlev, Herlev, Denmark.
  • Jens Overgaard
    Department of Clinical Medicine - Department of Experimental Clinical Oncology, Aarhus University, Aarhus N, Denmark.
  • Cai Grau
    Danish Centre of Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
  • Jeppe Friborg
    Danish Centre of Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
  • Christian Rønn Hansen
    Laboratory of Radiation Physics, Odense University Hospital, Odense, Denmark.

Keywords

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