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Organs at Risk

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A deep learning model based on Mamba for automatic segmentation in cervical cancer brachytherapy.

Scientific reports
This study developed and evaluated an automatic segmentation model based on the Mamba framework (AM-UNet) for rapid and precise delineation of high-risk clinical target volume (HRCTV) and organs at risk (OARs) in cervical cancer brachytherapy. Using ...

Geometric and Dosimetric Evaluation of a RayStation Deep Learning Model for Auto-Segmentation of Organs at Risk in a Real-World Head and Neck Cancer Dataset.

Clinical oncology (Royal College of Radiologists (Great Britain))
AIMS: To assess geometric accuracy and dosimetric impact of a deep learning segmentation (DLS) model on a large, diverse dataset of head and neck cancer (HNC) patients treated with intensity-modulated proton therapy (IMPT).

Closing the gap in plan quality: Leveraging deep-learning dose prediction for adaptive radiotherapy.

Journal of applied clinical medical physics
PURPOSE: Balancing quality and efficiency has been a challenge for online adaptive therapy. Most systems start the online re-optimization with the original planning goals. While some systems allow planners to modify the planning goals, achieving a hi...

Evaluation of deliverable artificial intelligence-based automated volumetric arc radiation therapy planning for whole pelvic radiation in gynecologic cancer.

Scientific reports
This study aimed to develop a deep learning (DL)-based deliverable whole pelvic volumetric arc radiation therapy (VMAT) for patients with gynecologic cancer using a prototype DL-based automated planning support system, named RatoGuide, to evaluate it...

Reinforcement learning-driven automated head and neck simultaneous integrated boost (SIB) radiation therapy: flexible treatment planning aligned with clinical preferences.

Physics in medicine and biology
Head-and-neck simultaneous integrated boost (SIB) treatment planning using intensity modulated radiation therapy is particularly challenging due to the proximity to organs-at-risk. Depending on the specific clinical conditions, different parotid-spar...

Towards improved prescription metrics in novel radiotherapy techniques: a machine learning study.

Physics in medicine and biology
FLASH radiotherapy (RT), microbeam RT (MRT) and minibeam RT (MBRT) are novel RT techniques that have been shown to reduce normal tissue complication probabilities, by modulating the dose distributions through different parameters in space and time. T...

Evaluating the dosimetric and positioning accuracy of a deep learning based synthetic-CT model for liver radiotherapy treatment planning.

Biomedical physics & engineering express
An MRI-only workflow requires synthetic computed tomography (sCT) images to enable dose calculation. This study evaluated the dosimetric and patient positioning accuracy of deep learning-generated sCT for liver radiotherapy.sCT images were generated ...

Clinically applicable semi-supervised learning framework for multiple organs at risk and tumor delineation in lung cancer brachytherapy.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
PURPOSE: The generalization ability of deep learning-based automatic segmentation techniques for lung cancer in practical clinical applications remains under-validated. We reported an investigation that validated a robust semi-supervised conditional ...

Feasibility study of automatic radiotherapy treatment planning for cervical cancer using a large language model.

Radiation oncology (London, England)
BACKGROUND: Radiotherapy treatment planning traditionally involves complex and time-consuming processes, often relying on trial-and-error methods. The emergence of artificial intelligence, particularly Large Language Models (LLMs), surpassing human c...

Patient-specific uncertainty calibration of deep learning-based autosegmentation networks for adaptive MRI-guided lung radiotherapy.

Physics in medicine and biology
Uncertainty assessment of deep learning autosegmentation (DLAS) models can support contour corrections in adaptive radiotherapy (ART), e.g. by utilizing Monte Carlo Dropout (MCD) uncertainty maps. However, poorly calibrated uncertainties at the patie...