CURATE.AI COR-Tx platform as a digital therapy and digital diagnostic for cognitive function in patients with brain tumour postradiotherapy treatment: protocol for a prospective mixed-methods feasibility clinical trial.

Journal: BMJ open
Published Date: Oct 24, 2023

Abstract

INTRODUCTION: Conventional interventional modalities for preserving or improving cognitive function in patients with brain tumour undergoing radiotherapy usually involve pharmacological and/or cognitive rehabilitation therapy administered at fixed doses or intensities, often resulting in suboptimal or no response, due to the dynamically evolving patient state over the course of disease. The personalisation of interventions may result in more effective results for this population. We have developed the CURATE.AI COR-Tx platform, which combines a previously validated, artificial intelligence-derived personalised dosing technology with digital cognitive training.

Authors

  • Alexandria Remus
    Heat Resilence and Performance Centre, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Xavier Tadeo
    The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Grady Ng Shi Kai
    The N.1 Institute for Health (N1), National University of Singapore, Singapore.
  • Agata Blasiak
    The N.1 Institute for Health (N.1), National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.
  • Theodore Kee
  • Smrithi Vijayakumar
    The N.1 Institute for Health (N.1), National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.
  • Le Nguyen
    The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Marlena N Raczkowska
    The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Qian Yee Chai
    Department of Radiation Oncology, National University Cancer Institute Singapore, National University Hospital, Singapore.
  • Fatin Aliyah
    Department of Radiation Oncology, National University Cancer Institute Singapore, National University Hospital, Singapore.
  • Yaromir Rusalovski
    The N.1 Institute for Health (N1), National University of Singapore, Singapore.
  • Kejia Teo
    Division of Neurosurgery, University Surgical Centre, National University Hospital, Singapore.
  • Tseng Tsai Yeo
    Division of Neurosurgery, University Surgical Centre, National University Hospital, Singapore.
  • Andrea Li Ann Wong
    Department of Hematology-Oncology, National University Cancer Institute Singapore, National University Hospital, Singapore.
  • David Chia
    School of Dentistry, University of California Los Angeles, Los Angeles, CA, USA.
  • Christopher L Asplund
    The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Dean Ho
    The N.1 Institute for Health (N.1), National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.
  • Balamurugan A Vellayappan
    Department of Radiation Oncology, National University Cancer Institute Singapore, National University Hospital, Singapore, Singapore.

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