High-dose atorvastatin versus moderate dose on early vascular protection after ST-elevation myocardial infarction.

Journal: Drug design, development and therapy
PMID: 29270001

Abstract

BACKGROUND AND AIM: Clinical benefits of early high-dose statin therapy after acute coronary syndromes are widely known; however, there is poor evidence on the specific setting of ST-elevation myocardial infarction (STEMI) and dose-dependent effects of this therapy on endothelial function and inflammatory biomarkers in the most vulnerable phase after acute coronary syndromes: the postdischarge period. In our study, we compared the short-term effects of high (80 mg) vs moderate doses of atorvastatin (20 mg) in patients with STEMI undergoing primary percutaneous coronary intervention on endothelial function and vascular inflammation. The aim of our study was the evaluation of dose-dependent short-term effects.

Authors

  • Mara Gavazzoni
    Cardiology Department, University of Brescia, Spedali Civili of Brescia, Brescia.
  • Elio Gorga
    Cardiology Department, University of Brescia, Spedali Civili of Brescia, Brescia.
  • Giuseppe Derosa
    Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico San Matteo.
  • Pamela Maffioli
    Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico San Matteo.
  • Marco Metra
    Cardiology Department, University of Brescia, Spedali Civili of Brescia, Brescia.
  • Riccardo Raddino
    Cardiology Department, University of Brescia, Spedali Civili of Brescia, Brescia.

Keywords

External Resources

Popular Topics
Recent Journals