AIMC Topic: Endothelial Cells
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Nucleic acid spheres for treating capillarisation of liver sinusoidal endothelial cells in liver fibrosis.
Nature communications
May 15, 2025
Liver sinusoidal endothelial cells (LSECs) lose their characteristic fenestrations and become capillarized during the progression of liver fibrosis. Mesenchymal stem cell (MSC) transplantation can reverse this capillarization and reduce fibrosis, but...
The role of endothelial cell-related gene COL1A1 in prostate cancer diagnosis and immunotherapy: insights from machine learning and single-cell analysis.
Biology direct
Jan 8, 2025
BACKGROUND: Endothelial cells are integral components of the tumor microenvironment and play a multifaceted role in tumor immunotherapy. Targeting endothelial cells and related signaling pathways can improve the effectiveness of immunotherapy by norm...
3D electron microscopy for analyzing nanoparticles in the tumor endothelium.
Proceedings of the National Academy of Sciences of the United States of America
Dec 12, 2024
Delivering medical agents to diseased tissues has been challenging, leading researchers to study the in vivo transport process in the body for improving delivery. Many imaging techniques exist for mapping the distribution of medical agent-carrying na...
Predicting blood-brain barrier permeability of molecules with a large language model and machine learning.
Scientific reports
Jul 9, 2024
Predicting the blood-brain barrier (BBB) permeability of small-molecule compounds using a novel artificial intelligence platform is necessary for drug discovery. Machine learning and a large language model on artificial intelligence (AI) tools improv...
Boosting Clear Cell Renal Carcinoma-Specific Drug Discovery Using a Deep Learning Algorithm and Single-Cell Analysis.
International journal of molecular sciences
Apr 8, 2024
Clear cell renal carcinoma (ccRCC), the most common subtype of renal cell carcinoma, has the high heterogeneity of a highly complex tumor microenvironment. Existing clinical intervention strategies, such as target therapy and immunotherapy, have fail...
Machine learning based endothelial cell image analysis of patients undergoing descemet membrane endothelial keratoplasty surgery.
Biomedizinische Technik. Biomedical engineering
Mar 18, 2024
OBJECTIVES: In this study, we developed a machine learning approach for postoperative corneal endothelial cell images of patients who underwent Descemet's membrane keratoplasty (DMEK).
Combination Therapy-Based Adaptive Control for Organism Using Medicine Dosage Regulation Mechanism.
IEEE transactions on cybernetics
Dec 20, 2023
In this article, the optimal control strategy for organism is investigated by using the adaptive dynamic programming (ADP) method under the architecture of nonzero-sum games (NZSGs). First, a tumor model is established to formulate the interaction re...
Rapid Quantification of Microvessels of Three-Dimensional Blood-Brain Barrier Model Using Optical Coherence Tomography and Deep Learning Algorithm.
Biosensors
Aug 15, 2023
The blood-brain barrier (BBB) is a selective barrier that controls the transport between the blood and neural tissue features and maintains brain homeostasis to protect the central nervous system (CNS). models can be useful to understand the role of...
Deciphering ligand-receptor-mediated intercellular communication based on ensemble deep learning and the joint scoring strategy from single-cell transcriptomic data.
Computers in biology and medicine
Jun 12, 2023
BACKGROUND: Cell-cell communication in a tumor microenvironment is vital to tumorigenesis, tumor progression and therapy. Intercellular communication inference helps understand molecular mechanisms of tumor growth, progression and metastasis.
Adaptive fuzzy control of drug delivery in cancer treatment using combination of chemotherapy and antiangiogenic therapy.
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Feb 11, 2023
This paper introduces the adaptive fuzzy control scheme as a promising control technique for cancer treatment from a theoretical point of view. A mathematical model describing the dynamics of tumor growth under the drug interventions of chemotherapy ...
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