Anti-aging factor, serum alpha-Klotho, as a marker of acute physiological stress, and a predictor of ICU mortality, in patients with septic shock.

Journal: Journal of critical care
PMID:

Abstract

PURPOSE: Genetic deletions decreasing serum alpha-Klotho (alpha-KL) have been associated with rapid aging, multi-organ failure and increased mortality in experimental sepsis. We hypothesized that lower alpha-KL obtained at the onset of septic shock correlates with higher mortality.

Authors

  • Peter A Abdelmalik
    Department of Neurology, State University of New York, University at Buffalo, Buffalo, NY 14202, United States. Electronic address: peterabd@buffalo.edu.
  • Robert D Stevens
    Department of Anesthesia and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
  • Sarabdeep Singh
    Department of Anesthesia and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
  • John Skinner
    Department of Anesthesia and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
  • J Ricardo Carhuapoma
    Department of Anesthesia and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
  • Sanjeev Noel
    Division of Nephrology, Department of Medicine, The Johns Hopkins University, Baltimore, MD 21287, United States.
  • Roger Johns
    Department of Anesthesia and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
  • Ralph J Fuchs
    Department of Anaesthesiology, The University of Auckland, Grafton, Auckland, New Zealand; Hauora Tairāwhiti District Health Board, Gisborne 4040, New Zealand.