Deep learning quantification reveals a fundamental prognostic role for ductular reaction in biliary atresia.

Journal: Hepatology communications
PMID:

Abstract

BACKGROUND: We aimed to quantify ductular reaction (DR) in biliary atresia using a neural network in relation to underlying pathophysiology and prognosis.

Authors

  • Iiris Nyholm
    Section of Pediatric Surgery, Pediatric Liver and Gut Research Group, Children and Adolescent Department, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Nelli Sjöblom
    Department of Pathology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 3, 00290, Helsinki, Finland. nelli.sjoblom@hus.fi.
  • Marjut Pihlajoki
    Pediatric Research Center, Children and Adolescent Department, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Maria Hukkinen
    Section of Pediatric Surgery, Pediatric Liver and Gut Research Group, Children and Adolescent Department, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Jouko Lohi
    Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Päivi Heikkilä
    Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Aino Mutka
    Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Timo Jahnukainen
    Department of Pediatric Nephrology and Transplantation, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Mark Davenport
    Department of Pediatric Surgery, King's College Hospital, London, UK.
  • Markku Heikinheimo
    Pediatric Research Center, Children and Adolescent Department, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Johanna Arola
  • Mikko P Pakarinen
    Department of Pediatric Surgery, University of Helsinki Children's Hospital Unit of Pediatric Surgery, Helsinki, Finland.