Deciphering the impact of senescence in kidney transplant rejection: An integrative machine learning and multi-omics analysis via bulk and single-cell RNA sequencing.

Journal: PloS one
PMID: 39602449

Abstract

BACKGROUND: The demographic shift towards an older population presents significant challenges for kidney transplantation (KTx), particularly due to the vulnerability of aged donor kidneys to ischemic damage, delayed graft function, and reduced graft survival. KTx rejection poses a significant threat to allograft function and longevity of the kidney graft. The relationship between senescence and rejection remains elusive and controversial.

Authors

  • Xihao Shen
    Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
  • Jiyue Wu
    Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
  • Feilong Zhang
    Beijing University of Chinese Medicine, Beijing 100029, China.
  • Qing Bi
    Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
  • Zejia Sun
    Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
  • Wei Wang
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.

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