Computational staining of CD3/CD20 positive lymphocytes in human tissues with experimental confirmation in a genetically engineered mouse model.

Journal: Frontiers in immunology
PMID: 39530103

Abstract

INTRODUCTION: Immune dysregulation plays a major role in cancer progression. The quantification of lymphocytic spatial inflammation may enable spatial system biology, improve understanding of therapeutic resistance, and contribute to prognostic imaging biomarkers.

Authors

  • Xiang Li
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
  • Casey C Heirman
    Medical Physics Graduate Program, Duke University, Durham, NC, United States.
  • Ashlyn G Rickard
    Department of Radiation Oncology, Duke University, Durham, NC, United States.
  • Gina Sotolongo
    Department of Pathology, Duke University, Durham, NC, United States.
  • Rico Castillo
    Department of Radiation Oncology, Duke University, Durham, NC, United States.
  • Temitayo Adanlawo
    Department of Radiation Oncology, Duke University, Durham, NC, United States.
  • Jeffery I Everitt
    Department of Pathology, Duke University, Durham, NC, United States.
  • Jeffery B Hodgin
    Department of Pathology, University of Michigan, Ann Arbor, MI, United States.
  • Tammara L Watts
    Department of Head and Neck Surgery & Communication Sciences, Duke University, Durham, NC, United States.
  • Andrew Janowczyk
    Biomedical Engineering Department, Case Western Reserve University, Cleveland, Ohio.
  • Yvonne M Mowery
    Department of Radiation Oncology, Duke University, Durham, NC.
  • Laura Barisoni
    Department of Pathology and Medicine, Division of Nephrology, Duke University, Durham, North Carolina, USA.
  • Kyle J Lafata
    Department of Radiology, Duke University School of Medicine, Durham, NC, USA. kyle.lafata@duke.edu.

Keywords

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