AIMC Topic: CD3 Complex

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Predictive biomarkers validation of CD3 cell apheresis yield in CAR-T manufacturing for diffuse large B-cell lymphoma: a machine learning approach.

Scientific reports
Chimeric antigen receptor (CAR) T-cell therapy has shown significant success in treating diffuse large B-cell lymphoma (DLBCL). The initial step involves collecting autologous CD3 lymphocytes through apheresis, in which obtaining an adequate CD3 cell...

Preoperative MRI-based radiomics analysis of intra- and peritumoral regions for predicting CD3 expression in early cervical cancer.

Scientific reports
The study investigates the correlation between CD3 T-cell expression levels and cervical cancer (CC) while developing a magnetic resonance (MR) imaging-based radiomics model for preoperative prediction of CD3 T-cell expression levels. Prognostic corr...

Computational staining of CD3/CD20 positive lymphocytes in human tissues with experimental confirmation in a genetically engineered mouse model.

Frontiers in immunology
INTRODUCTION: Immune dysregulation plays a major role in cancer progression. The quantification of lymphocytic spatial inflammation may enable spatial system biology, improve understanding of therapeutic resistance, and contribute to prognostic imagi...

Combination of CDX2 H-score quantitative analysis with CD3 AI-guided analysis identifies patients with a good prognosis only in stage III colon cancer.

European journal of cancer (Oxford, England : 1990)
AIM: Stratification of colon cancer (CC) of patients with stage II and III for risk of relapse is still needed especially to drive adjuvant therapy administration. Our study evaluates the prognostic performance of two known biomarkers, CDX2 and CD3, ...

Identification of novel biomarkers in Hunner's interstitial cystitis using the CIBERSORT, an algorithm based on machine learning.

BMC urology
BACKGROUND:  Hunner's interstitial cystitis (HIC) is a complex disorder characterized by pelvic pain, disrupted urine storage, and Hunner lesions seen on cystoscopy. There are few effective diagnostic biomarkers. In the present study, we used the nov...