"Dictionary of immune responses" reveals the critical role of monocytes and the core target IRF7 in intervertebral disc degeneration.

Journal: Frontiers in immunology
PMID:

Abstract

BACKGROUND: Intervertebral disc degeneration (IDD) is widely regarded as the primary contributor to low back pain(LBP). As an immune-privileged organ, upon the onset of IDD, various components of the nucleus pulposus (NP) are exposed to the host's immune system, accumulating cytokines. Cytokines facilitate intercellular communication within the immune system, induce immune cells polarisation, and exacerbate oxidative stress in IDD.

Authors

  • Peichuan Xu
    Department of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
  • Kaihui Li
    Department of Stomatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
  • Jinghong Yuan
    Department of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
  • Jiangminghao Zhao
    Department of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
  • Huajun Pan
    Department of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
  • Chongzhi Pan
    Department of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
  • Wei Xiong
    Department of Nutrition and Health, China Agricultural University, Beijing 100193, China; Food Laboratory of Zhongyuan, Luohe, Henan 462300, China. Electronic address: xiongwei910702@126.com.
  • Jianye Tan
    Department of Orthopaedics, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
  • Tao Li
    Department of Emergency Medicine, Jining No.1 People's Hospital, Jining, China.
  • Guanfeng Huang
    Department of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
  • Xiaolong Chen
    Department of Orthopedics & Elderly Spinal Surgery, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
  • Xinxin Miao
    Department of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
  • Dingwen He
    Department of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
  • Xigao Cheng
    Department of Orthopaedics, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China. Ndefy12160@ncu.edu.cn.