AIMC Topic: Nucleus Pulposus

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"Dictionary of immune responses" reveals the critical role of monocytes and the core target IRF7 in intervertebral disc degeneration.

Frontiers in immunology Oct 17, 2024
BACKGROUND: Intervertebral disc degeneration (IDD) is widely regarded as the primary contributor to low back pain(LBP). As an immune-privileged organ, upon the onset of IDD, various components of the nucleus pulposus (NP) are exposed to the host's im...
Humans Machine Learning Cytokines Animals Gene Expression Profiling Gene Regulatory Networks Mice Computational Biology Monocytes Intervertebral Disc Degeneration Interferon Regulatory Factor-7 Nucleus Pulposus
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Combining the probabilistic finite element model and artificial neural network to study nutrient levels in the human intervertebral discs.

Clinical biomechanics (Bristol, Avon) Sep 27, 2024
BACKGROUND: Diffusion distance and diffusivity are known to affect nutrient transport rates, but the probabilistic analysis of these two factors remains vacant. There is a lack of effective tools to evaluate disc nutrient levels.
Humans Neural Networks, Computer Computer Simulation Female Adult Male Middle Aged Models, Statistical Oxygen Glucose Models, Biological Nutrients Finite Element Analysis Intervertebral Disc Nucleus Pulposus Annulus Fibrosus
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Deep Learning Assisted Classification of T1ρ-MR Based Intervertebral Disc Degeneration Phases.

Journal of magnetic resonance imaging : JMRI Jul 15, 2024
BACKGROUND: According to the T1ρ value of nucleus pulposus, our previous study has found that intervertebral disc degeneration (IDD) can be divided into three phases based on T1ρ-MR, which is helpful for the selection of biomaterial treatment timing....
Humans Retrospective Studies Female Reproducibility of Results Aged Adult Male Middle Aged Deep Learning ROC Curve Image Processing, Computer-Assisted Magnetic Resonance Imaging Image Interpretation, Computer-Assisted Intervertebral Disc Degeneration Low Back Pain Intervertebral Disc Nucleus Pulposus
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