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Nucleus Pulposus

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"Dictionary of immune responses" reveals the critical role of monocytes and the core target IRF7 in intervertebral disc degeneration.

Frontiers in immunology 39483476
BACKGROUND: Intervertebral disc degeneration (IDD) is widely regarded as the primary contributor to low back pain(LBP). As an immune-privileged organ, upon the onset of IDD, various components of the nucleus pulposus (NP) are exposed to the host's im...
Animals Computational Biology Cytokines Gene Expression Profiling Gene Regulatory Networks Humans Interferon Regulatory Factor-7 Intervertebral Disc Degeneration Machine Learning Mice Monocytes Nucleus Pulposus
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Deep Learning Assisted Classification of T1ρ-MR Based Intervertebral Disc Degeneration Phases.

Journal of magnetic resonance imaging : JMRI 39010746
BACKGROUND: According to the T1ρ value of nucleus pulposus, our previous study has found that intervertebral disc degeneration (IDD) can be divided into three phases based on T1ρ-MR, which is helpful for the selection of biomaterial treatment timing....
Adult Aged Deep Learning Female Humans Image Interpretation, Computer-Assisted Image Processing, Computer-Assisted Intervertebral Disc Intervertebral Disc Degeneration Low Back Pain Magnetic Resonance Imaging Male Middle Aged Nucleus Pulposus Reproducibility of Results Retrospective Studies ROC Curve
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Combining the probabilistic finite element model and artificial neural network to study nutrient levels in the human intervertebral discs.

Clinical biomechanics (Bristol, Avon) 39366140
BACKGROUND: Diffusion distance and diffusivity are known to affect nutrient transport rates, but the probabilistic analysis of these two factors remains vacant. There is a lack of effective tools to evaluate disc nutrient levels.
Adult Annulus Fibrosus Computer Simulation Female Finite Element Analysis Glucose Humans Intervertebral Disc Male Middle Aged Models, Biological Models, Statistical Neural Networks, Computer Nucleus Pulposus Nutrients Oxygen
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